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Dr Christiane FenskeMy background is academic, having lectured and carried out research in molecular genetics. In addition to my current responsibilities as an administrator, my research group has developed, carrying out research into an alternative accurate test for prostate cancer. We have been very generously funded by the Everard and Mina Goodman Charitable Foundation, Swire Foundation and the Prostate Research Campaign. The PRC has been particularly supportive, offering encouragement, and featuring our work in their newsletter. The Prostate Cancer Research Group at SGUL includes Christodoulos Pipinikas, and Professor Nick Carter, and includes invaluable collaborators — Dr Tom Swallow, Dr Chris Anderson and Dr Cathy Corbishley in the Urology Department at St George’s Hospital, Professor Roger Kirby at The Prostate Centre. Dr Corbishley’s prostate cancer database, established in 1995 is a crucial and invaluable tool for our research. The research involves quantitative RT-PCR, and analysis of potential cancer-, prostate- and prostate cancer markers. Together with support from Westfocus and the SGUL Enterprise Centre a patent has been successfully filed, and is now entering the international phase of examination. The test is now at a point of further development and validation, with the aim of implementation into routine procedures.
Recent Publications Pipinikas CP, Nair SB, Kirby RS, Carter ND, CD Fenske. ‘Measurement of blood E2F3 mRNA in prostate cancer by quantitative RT-PCR — A preliminary study’ (2007) Biomarkers (in press) Waltham M, Burnand K, Fenske C, Modarai, B, Humphries J, Smith A (2005) ‘Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution’ J.Vas.Surg42: 1183-1189 Yusuf S, Fenske C, Dalageorgou C, Carter N , Al Saady N, Maarouf N, Camm J (2003) ‘ Modulation of 5-hydroxytryptamine 4 (5HT4) receptor isoform expression predisposes to atrial fibrillation after coronary artery bypass surgery. Abstract accepted for presentation at ASHG Los Angeles CD Fenske, C Pipinikas, LA Gunaratne, A Chamberlain, PBanerjee, N Carter (2002) 'Methylation and loss of heterozygosity in cyld, a tumour suppressor in Brooke-Spiegler syndrome’ Biochem Soc Trans Fredericks S, Bainbridge K, Fenske CD, Gaze D, Collinson PO, Carter ND, Holt DW (2002) ‘Cardiac troponin-I content of skeletal muscle in patients with renal failure’. Clin Biochem. 35: 421-3. Afzal AR, Rajab A, Fenske C, Crosby A, Lahiri N, Ternes-Pereira E, Murday VA, Houlston R, Patton MA, Jeffery S. (2000) ‘Linkage of recessive Robinow syndrome to a 4 cM interval on chromosome 9q22’ Hum Genet. 106: 351-4. Ion A, Crosby AH, Kremer H, Kenmochi N, Van Reen M, Fenske C, Van Der Burgt I, Brunner HG, Montgomery K, Kucherlapati RS, Patton MA, Page C, Mariman E, Jeffery S (2000) ‘Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6’ Med Genet. 37:884-6. Afzal AR, Rajab A, Fenske CD, Oldridge M, Elanko N, Ternes-Pereira E, Tuysuz B, Murday VA, Patton MA, Wilkie AO, Jeffery S (2000) ‘Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2’ Nat Genet.25:419-22. Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, C Fenske, Rasmussen S. (2000) ‘Identification of the familial cylindromatosis tumour-suppressor gene’ Nat Genet. 25:160-5. Fenske C, Banerjee P, Holden C, Carter N. (2000) ‘Brooke-Spiegler syndrome locus assigned to 16q12-q13’ J Invest Dermatol. 114:1057-8. Afzal AR, Rajab A, Fenske C, Crosby A, Lahiri N, Ternes-Pereira E, Murday VA, Houlston R, Patton MA, Jeffery S. (2000) Linkage of recessive Robinow syndrome to a 4 cM interval on chromosome 9q22.’ Hum Genet.106:351-4. Abstracts Pipinikas CP, Nair SB, Kirby RS, Carter ND, CD Fenske. ‘Up-regulation of hypoxia-inducible factor 1 alpha gene expression as an early event in prostate cancer development’. Presentation on BioScience by Britain’s Top Younger Researchers, House of Commons, 8 May 2006, and at Annual EAU Meeting, 5-8 April 2006, Paris, France Nair SB, Pipinikas CP, Kirby RS, Carter ND, CD Fenske. ‘Molecular diagnosis and staging of prostate cancer using clusterin in real time reverse transcription polymerase chain reaction (RT-PCR)’. AUA 2006 CP Pipinikas, SB Nair, RS Kirby, ND Carter and CD Fenske. ‘Hypoxia-inducible factor 1 alpha gene expression levels in prostate cancer measured by quantitative reverse-transcriptase polymerase chain reaction’. ASHG 2005 (Salt Lake City, Utah) Pipinikas CP, Nair SB, Kirby RS, Carter ND, CD Fenske. ‘Molecular Biopsy for Prostate Cancer using Carbonic Anhydrase XII Quantitative RT-PCR’. SURG September 2004; BAUS Manchester 2004 Pipinikas CP, Nair SB, Konstantinou KI, Kirby RS, Carter ND, Fenske CD. ‘Sensitive and non-invasive diagnosis of Prostate Cancer using E2F3 Quantitative RT-PCR’. BAUS Manchester 2004 Nair SB, Pipinikas CP, Konstantinou KI, Kirby RS, Carter ND, Fenske CD. ‘Quantitative alpha-methylacyl coenzyme A racemase (AMACR) polymerase chain reaction as a peripheral biomarker for prostate cancer’. AUA 2002 |
Dr Christiane Fenske
Division Manager
Section of Medical Genetics Tel: (+44)208 725 0229 |
