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Dr Aris T Papageorghiou

NAME

Aris T Papageorghiou

Research Status

Clinical Scientist

Academic Section

Obstetrics & Gynaecology

Phone Number

020 8725 1984

Email

apapageo@sgul.ac.uk

Research Interests

1. Placentation:
Pre-eclampsia - maternal cardiac function; screening.
Fetal growth restriction — screening; management.
Early pregnancy — early growth restriction;
2. Fetal therapy and multiple pregnancy:
Management of twin-twin transfusion syndrome.
Antenatal management of triplet pregnancy.
Growth in multiple pregnancies
3. Postpartum Hemorrhage:
Management strategies in massive postpartum haemorrhage.
4. Prenatal diagnosis:
Ultrasound based diagnosis of fetal abnormalities and screening for chromosomal defects.
5. Intrapartum fetal monitoring:
Use of fetal ECG in intrapartum monitoring.

MAJOR Research
Techniques

1. Prospective cohort studies
Placentation:
Uterine artery Doppler in the first and second trimester.
Maternal echocardiographic assessment.
Biochemical assessment using ischaemia modified albumin (IMA).
Fetal therapy and multiple pregnancy
Pregnancy outcome after Laser ablation of the vascular equator.
Embryo-reduction vs expectant management in triplet pregnancy.
Postpartum Hemorrhage
Management of massive PPH using balloon tamponade.
Prenatal diagnosis
Screening for chromosomal abnormalities in the first trimester.
Intrapartum fetal monitoring
Prosepective evaluation of fetal ECG in intrapartum monitoring.
2. Systematic reviews
Placentation:
Uterine artery Doppler and prediction of adverse pregnancy outcome.
Fetal therapy and multiple pregnancy
Embryo-reduction vs expectant management in triplet pregnancy.
Postpartum Hemorrhage
Systematic review of non-medical treatment for PPH.
3. Randomised controlled trials
Placentation:
Aspirin vs placebo in preventing pre-eclampsia in women with abnormal Uterine artery Doppler.
TRUFFLE (Trial of Umbilical and Fetal Flow in Europe) - international, multi-centre randomised trial comparing abnormal blood flow in the Ductus Venosus vs CTGin timing delivery in severely growth restricted infants.

Minor Research
Techniques

Retrospective cohort studies
Case control studies
Case reports.

RECENT PUBLICATIONS — ORIGINAL RESEARCH PAPERS

Articles 2005 -2007

  1. S.K.Doumouchtsis, A.T.Papageorghiou, S.Arulkumaran. Systematic Review of Conservative Management of Postpartum Hemorrhage: What to Do When Medical Treatment Fails. Obstet Gynecol Surv. 2007Aug;62(8):540-547.
  2. F.Prefumo, D.C.Gaze, A.T.Papageorghiou, P.O.Collinson, B.Thilaganathan. First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development. Hum Reprod. 2007 Jul;22(7):2029-32. Epub 2007 Apr 16.
  3. PMID: 17437959 [PubMed - in process] N.Fratelli, A.T.Papageorghiou, A.Bhide, A.Sharma, B.Okoye, B.Thilaganathan. Outcome of antenatally diagnosed abdominal wall defects. Ultrasound Obstet Gynecol. 2007 Aug 3;
  4. A.M.Ierullo, A.T.Papageorghiou, A.Bhide, N.Fratelli, B.Thilaganathan. Severe Twin-Twin Transfusion Syndrome: Outcome after Fetoscopic Laser Ablation of the Placental Vascular Equator. BJOG. 2007 Jun;114(6):689-93.
  5. N.Fratelli, A.T.Papageorghiou, F.Prefumo, S.Bakalis, T.Homfray, B.Thilaganathan. Outcome of prenatally diagnosed agenesis of the corpus callosum. Prenat Diagn. 2007 Jun;27(6):512-7.
  6. G.C.S.Smith, C.K.H.Yu, A.T.Papageorghiou, K.H.Nicolaides. Uterine artery Doppler and risk of spontaneous stillbirth. Obstet Gynecol. 2007 Jan;109(1):144-51.
  7. E.Kirk, A.T.Papageorghiou, G.Condous, C.Bottomley, T.Bourne. The accuracy of first trimester ultrasound in the diagnosis of hydatdiform mole. Ultrasound Obstet Gynecol.. 2007 Jan; 29(1):70-5.
  8. E.Kirk, A.T.Papageorghiou, G.Condous, C.Bottomley, T.Bourne. Hyperemesis gravidarum: is an ultrasound scan necessary? Hum Reprod. 2006 Sep;21(9):2440-2.
  9. A.T.Papageorghiou, V.Bakoulas, K.Avgidou, N.Sebire, K.H. Nicolaides. Risks of miscarriage or early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review. Hum Reprod. 2006 Jul;21(7):1912-7.
  10. F.Prefumo, G.Condous, A.T.Papageorghiou, B.Thilaganathan, T.Bourne. Do early pregnancy ultrasound measurements correlate with fetal nuchal translucency at 11-14 weeks? Ultrasound Obstet Gynecol. 2006 Jun;27(6):628-31.
  11. K.Spencer, C.K.Yu, M.Savvidou, A.T.Papageorghiou, K.H.Nicolaides. Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation. Ultrasound Obstet Gynecol. 2006 Jun;27(6):658-63.
  12. E.Fonseca, C.K.Yu, M.Singh, A.T.Papageorghiou, K.H.Nicolaides. Relationship between second-trimester uterine artery Doppler and spontaneous early preterm delivery. Ultrasound Obstet Gynecol. 2006 Mar;27(3):301-5.
  13. A.T.Papageorghiou, K.Avgidou, B.Nix, K.Spencer, K.H.Nicolaides. Sonographic screening for trisomy 13 at 11 to 13(+6) weeks of gestation. Am J Obstet Gynecol. 2006 Feb;194(2):397-401.
  14. A.T.Papageorghiou, C.K.H. Yu, I.Erasmus, H.S. Cuckle, K.H. Nicolaides Assessment Of Risk For The Development Of Pre-Eclampsia By Maternal Characteristics And Uterine Artery Doppler. BJOG. 2005 Jun;112(6):703-9.
  15. C.K.H.Yu, G.C.S.Smith, A.T.Papageorghiou, A.M.Cacho, K.H.Nicolaides. An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk women. Am J Obstet Gynecol. 2005 Aug;193(2):429-36.
  16. K.H. Nicolaides, F.A. Chervenak, L.B. McCullough, K.Avgidou, A.T. Papageorghiou. Evidence-based obstetric ethics and informed decision-making by pregnant women about invasive diagnosis after first-trimester assessment of risk for trisomy 21. Am J Obstet Gynecol. 2005 Aug;193(2):322-6.
  17. K. Avgidou, A.T.Papageorghiou, R.Bindra, K.Spencer, K.H. Nicolaides. Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies. Am J Obstet Gynecol. 2005 Jun;192(6):1761-7.
  18. S. Banerjee, A.Smallwood, A.E.Chambers, A.Papageorghiou, H.Loosfelt, K.Spencer, S.Campbell, K.Nicolaides. A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies. Reprod Biol Endocrinol. 2005 Jun 21;3(1):25.

RECENT REVIEWS / BOOK CHAPTERS

  1. Papageorghiou AT, Leslie K. Uterine artery Doppler in the prediction of adverse pregnancy outcome. Curr Opin Obstet Gynecol. 2007 Apr;19(2):103-9. Review.
  2. Papageorghiou AT, Campbell S. First trimester screening for preeclampsia. Curr Opin Obstet Gynecol. 2006 Dec;18(6):594-600. Review.
  3. Papageorghiou AT, Roberts N. Uterine artery Doppler screening for adverse pregnancy outcome. Curr Opin Obstet Gynecol. 2005 Dec;17(6):584-590.
  4. Thilaganathan B, Sairam S, Papageorghiou AT, Bhide A, (2006) Obstetric Ultrasound: A problem-based approach. Taylor and Francis, London
  5. Papageorghiou AT, Arulkumaran S (2006) Abdominal pain in pregnancy. In:S. Arulkumaran (ed) Emergencies in Obstetrics and Gynaecology. Oxford University Press, Oxford. [In Print]
  6. Papageorghiou AT, Arulkumaran S (2006) Convulsions in pregnancy. In:S. Arulkumaran (ed) Emergencies in Obstetrics and Gynaecology. Oxford University Press, Oxford. [In Print]
  7. Papageorghiou AT, Arulkumaran S (2006) Headache, feeling unwell and unusual behaviour in pregnancy. In: S. Arulkumaran (ed) Emergencies in Obstetrics and Gynaecology. Oxford University Press, Oxford. [In Print]
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