Research Interests |
The role of 5HT in sexual differentiation of the brain
5HT receptors in the regulation of LH release and sexual behaviour
“Apetite” hormones (MCH,?MSH, Orexin, Leptin)and their receptors in the regulation of LH release
The role of the brain area, the Zona Incerta, in reproduction |
MAJOR
Research
Techniques
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In vivo manipulations in rats
(systemic injections, gonadectomy, stereotaxic implantations and injections into the brain)
Behavioural tests in rodents
(sexual behaviour, sexual orientation, aggression, exploration, locomotion)
Radioimmunoassay(RIA) |
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Murray JF, Hahn JD, Kennedy AR, Small CJ, Bloom SR, Haskell-Luevano C, Coen CW, Wilson CA (2006) Evidence for a stimulatory action of Melanin concentrating hormone on Luteinizing hormone release involving MCH1 and Melanocortin-5 receptors. J. Neuroendocrinol. 18:157-167
Malik NM, Carter ND, Wilson CA, Scaramuzzi RJ, Stock MJ, Murray JF.(2005) Leptin expression in the fetus and placenta during mouse pregnancy. Placenta 26: 47-52
Murray JF, Dakin CL, Siddiqui A, Pellatt LJ, Ahmed S, Ormerod LJA, Swan AV, Davies DC, Wilson CA .(2004) Neonatal 5HT activity antagonises the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats.Europ. J.Neurosci. 19:387-395.
Siddiqui A, Abu-Amara M, Aldairy C, Hagan JJ, Wilson CA (2004) 5HT7 receptor subtype as a mediator of the serotonergic regulation of Luteinizing hormone release in the Zona Incerta. Europ. J. Pharmacol. 491; 77-84.
Small CJ, Goubillon M-L, Murray JF, Siddiqui A, Grimshaw SE, Young H, Sivanesan V, Kalamatianos T, Kennedy AR, Coen CW, Bloom SR, Wilson CA.(2003) Central Orexin A has site-specific effects in LH release in female rats. Endocrinology 144: 3225-3236.
Murray JF, Mercer JG, Adan RAH, Datta J, Aldairy C, Baker BI, Stock MJ, Wilson CA. (2000) The effect of Leptin on LH release is exerted in the Zona Incerta and mediated by MCH. J. Neuroendocrinol. 12:1133-1139. |
