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Professor Derek Cook

NAME

Derek Cook

Research Status

Professor Epidemiology 

Academic Section

Community Health Sciences

Phone Number

020 8725 5490 

Email

d.cook@sgul.ac.uk

Research Interests

Primary care epidemiology,Epidemiology of respiratory & cardiovascular disease, Indoor and outdoor air pollution, Early origins of adult disease, Life-course epidemiology,

Research Methods

Population surveys, cohort studies, systematic reviews of observational data, analyses of large primary care databases 

Fellowships

FFPH 2006

PUBLICATIONS2001 — 2008

2008

DeWilde S, Carey IM, Richards N, Whincup PH, Cook DG.Trends in secondary prevention of ischaemic heart disease in the UK 1994-2005: use of individual and combination treatment. Heart 2008;94:83-8 (DOI:10.1136/hrt.2006.111757)

Bremner SA, Carey IM, DeWilde S, Richards N, Maier WC, Hilton SR, Strachan DP, Cook DG. Infections in the first year of life and risk of later hay fever in two UK general practice databases. Allergy 2008 (In Press) (DOI:10.1111/j.1398-9995.2007.015999.x)

Shah S, Cook DG. Socio-economic determinants of casualty and NHS Direct use. J Pub Health 2008 (In Press)

2007

De Wilde S., Carey IM, Harris T, Richards N, Victor C, Hilton SR, Cook DG. Trends in potentially inappropriate prescribing amongst older UK primary care patients. Pharmacoepidemiol Drug Saf 2007; 16:658-667.

Ussher MH, Whincup PH, Cook DG, Owen CO.The relationship between physical acivity, sedentary behaviour and psychological wellbeing among adolescents. Social Psychiatry Psychiatr Epidemiol 2007;42:851-6 (DOI:10.1007/s00127-007-0232-x)

Huxley R, Owen CG, Whincup PH, Cook DG, Rich-Edwards J, Smith GD, Collins R. Is birth weight a risk factor for ischemic heart disease in later life? Am J Clin Nutr 2007; 85:1244-1250.

Carey IM, Dewilde S, Harris T, Whincup PH, Cook DG. Spurious trends in coronary heart disease incidence: unintended consequences of the new GP contract? British Journal of General Practice 2007; 57:486-489.

Bremner SA, Carey IM, Dewilde S, Richards N, Maier WC, Hilton SR, Strachan DP, Cook DG. Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever. Clin Exp Allergy 2007; 37:512-517.

2006

De Wilde S, Carey IM, Emmas C, Richards N, Cook DG. Trends in the prevalence of diagnosed atrial fibrillation, its treatment with anticoagulation and predictors of such treatment in UK primary care. Heart 2006; 92:1064-1070.

Harris T, Cook DG, Victor C, De Wilde S, Beighton C. Onset and persistence of depression in older people--results from a 2-year community follow-up study. Age Ageing 2006; 35:25-32.

Lawlor DA, Owen CG, Davies AA, Whincup PH, Ebrahim S, Cook DG, Davey SG. Sex differences in the association between birth weight and total cholesterol. A meta-analysis. Ann Epidemiol 2006; 16:19-25.

Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr 2006; 84:1043-1054.

Owen CG, Carey IM, De Wilde S., Whincup PH, Wormald R, Cook DG. The epidemiology of medical treatment for glaucoma and ocular hypertension in the United Kingdom: 1994 to 2003. Br J Ophthalmol 2006; 90:861-868.

Rodriguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, Miller GJ, Cooper CC, Cook DG, Whincup PH, Day IN. A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. Pharmacogenet Genomics 2006; 16:15-23.

Rudnicka AR, Mt-Isa S, Owen CG, Cook DG, Ashby D. Variations in Primary Open-Angle Glaucoma Prevalence by Age, Gender, and Race: A Bayesian Meta-Analysis. Invest Ophthalmol Vis Sci 2006; 47:4254-4261.

Smeeth L, Donnan PT, Cook DG. The use of primary care databases: case-control and case-only designs. Fam Pract 2006; 23:597-604.

2005

Bremner SA, Carey IM, De Wilde S, Richards N, Maier WC, Hilton S, Strachan DP, Cook DG. Timing of routine immunisations and subsequent hay fever risk. Arch Dis Child 2005; 90:567-573.

de Lusignan S, Sismanidis C, Carey IM, De Wilde S, Richards N, Cook DG. Trends in the prevalence and management of diagnosed type 2 diabetes 1994-2001 in England and Wales. BMC Fam Pract 2005; 6:13.

Harris T, Cook DG, Victor C, Beighton C, De Wilde S, Carey IM. Linking questionnaires to primary care records: factors affecting consent in older people. J Epidemiol Community Health 2005; 59:336-338.

Harris T, Cook DG, Victor CR, Rink P, Beighton C, De Wilde S, Carey IM. Are depression, anxiety and health beliefs important predictors of older people's primary care consulting? Age Ageing 2005; 34:398-401.

Huang S, Cook DG, Hinks LJ, Chen XH, Ye S, Gilg JA, Jarvis MJ, Whincup PH, Day IN. CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. Pharmacogenet Genomics 2005; 15:839-850.

Miller MA, Kerry SM, Dong Y, Sagnella GA, Cook DG, Cappuccio FP. Circulating soluble E-selectin levels and the Ser128Arg polymorphism in individuals from different ethnic groups. Nutr Metab Cardiovasc Dis 2005; 15:65-70.

Owen C, Martin RM, Whincup PH, Smith GD, Gillman MW, Cook DG. The effect of infant feeding on mean BMI throughout life; a quantitative review of published and unpublished observational evidence. Amer J Clin Nutr 2005;82:1298-307

Owen CG, Martin RM, Whincup PH, Davey-Smith G, Cook DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics 2005; 115:1367-1377.

Owen CG, Whincup PH, Cook DG. Are early life factors responsible for international differences in adult blood pressure? An ecological study. Int J Epidemiol 2005; 34:649-654.

Whincup PH, Gilg JA, Owen CG, Odoki K, Alberti KG, Cook DG. British South Asians aged 13-16 years have higher fasting glucose and insulin levels than Europeans. Diabet Med 2005; 22:1275-1277.

Whincup PH, Owen CG, Sattar N, Cook DG. School dinners and markers of cardiovascular health and type 2 diabetes in 13-16 year olds: cross sectional study. BMJ 2005; 331:1060-1061.

Whincup PH, Cook DG, Geleijnse JM. A life course approach to blood pressure. In: Khu D, Ben-Shlomo Y, editors. A life course approach to chronic disease epidemiology. Second ed. Oxford: Oxford University Press; 2005. 218-239.

Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, Deanfield JE. Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 2005; 112:1789-1797.

2004

Barbato A, Cappuccio FP, Folkerd EJ, Strazzullo P, Sampson B, Cook DG, Alberti KGMM. Metabolic syndrome and renal sodium handling in three ethnic groups living in England. Diabetologia 2004; 47:40-46.

Carey IM, Cook DG, De Wilde S, Bremner SA, Richards N, Caine S, Strachan DP, Hilton SR. Developing a large electronic primary care database (Doctors' Independent Network) for research. Int J Med Inf 2004; 73:443-453.

De Wilde S, Carey IM, Bremner SA, Richards N, Hilton SR, Strachan DP, Cook DG. A comparison of the recording of 30 common childhood conditions in the Doctors' Independent Network and General Practice research databases. Health Statistics Quarterly 2004; Summer 2004:21-30.

Harris T, Cook DG, Victor CR, Beighton C, De Wilde S, Carey IM. Linking survey data with computerised records to predict consulting by older people. Br J Gen Pract 2004; 54:928-931.

Huxley R, Owen CG, Whincup PH, Cook DG, Colman S, Collins R. Birth weight and subsequent cholesterol levels: exploration of the "fetal origins" hypothesis. JAMA 2004; 292:2755-2764.

Miller MA, Kerry SM, Cook DG, Cappuccio FP. Cellular adhesion molecules and blood pressure: interaction with sex in a multi-ethnic population. J Hypertens 2004; 22:705-711.

Whincup PH, Gilg JA, Emberson JR, Jarvis MJ, Feyerabend C, Bryant A, Walker M, Cook DG. Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement. BMJ 2004; 329:200-204.

2003

Bremner SA, Carey IM, De Wilde S, Richards N, Maier WC, Hilton SR, Strachan DP, Cook DG. Early-life exposure to antibacterials and the subsequent development of hayfever in childhood in the UK: case-control studies using the General Practice Research Database and the Doctors' Independent Network. Clin Exp Allergy 2003; 33:1518-1525.

Carey IM, Cook DG, De Wilde S, Bremner SA, Richards N, Caine S, Strachan DP, Hilton SR. Implications of the problem orientated medical record (POMR) for research using electronic GP databases: a comparison of the Doctors Independent Network Database (DIN) and the General Practice Research Database (GPRD). BMC Fam Pract 2003; 4:14.

De Wilde S, Carey IM, Bremner SA, Richards N, Hilton SR, Cook DG. Evolution of statin prescribing 1994-2001: a case of agism but not of sexism? Heart 2003; 89:417-421.

Harris T, Cook DG, Victor C, Rink E, Mann AH, Shah S, De Wilde S, Beighton C. Predictors of depressive symptoms older people--a survey of two general practice populations. Age Ageing 2003; 32:510-518.

Miller MA, Sagnella GA, Kerry SM, Strazzullo P, Cook DG, Cappuccio FP. Ethnic differences in circulating soluble adhesion molecules: the Wandsworth Heart and Stroke Study. Clin Sci (Lond) 2003; 104:591-598.

Owen CG, Whincup PH, Odoki K, Gilg JA, Cook DG. Birth weight and blood cholesterol level: a study in adolescents and systematic review. Pediatrics 2003; 111:1081-1089.

Owen CG, Whincup PH, Gilg JA, Cook DG. Effect of breast feeding in infancy on blood pressure in later life: systematic review and meta-analysis. BMJ 2003; 327:1189-1195.

2002

Cappuccio FP, Bell R, Perry IJ, Gilg J, Ueland PM, Refsum H, Sagnella GA, Jeffery S, Cook DG. Homocysteine levels in men and women of different ethnic and cultural background living in England. Atherosclerosis 2002; 164:95-102.

Court CS, Cook DG, Strachan DP. The descriptive epidemiology of house dust mite-specific and total immunoglobin E in England using a nationally representative sample. Clin Exp Allergy 2002; 32:1033-1041.

Court CS, Cook DG, Strachan DP. Comparative epidemiology of atopic and non-atopic wheeze and diagnosed asthma in a national sample of English adults. Thorax 2002; 57:951-957.

Harris TJ, Cook DG, Shah S, Victor CR, De Wilde S, Beighton C, Rink E. Mammography uptake predictors in older women. Fam Pract 2002; 19:661-6

Owen CG, Whincup PH, Odoki K, Gilg JA, Cook DG. Infant feeding and blood cholesterol: a study in adolescents and a systematic review. Pediatrics 2002; 110:597-608.

Reid F, Cook DG, Whincup PH. Use of statins in the secondary prevention of coronary heart disease: is treatment equitable? Heart 2002; 88:15-19.

Victor CR, Scambler SJ, Shah S, Cook DG, Harris T, Rink EM, De Wilde S. Has loneliness amongst older people increased?An investigation into variations between cohorts. Ageing and Society 2002; 22:585-597.

Whincup PH, Gilg JA, Papacosta O, Seymour C, Miller GJ, Alberti KG, Cook DG. Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children. BMJ 2002; 324:635.

2001

Blackwood AM, Sagnella GA, Cook DG, Cappuccio FP. Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study. J Hum Hypertens 2001; 15:229-237.

Cappuccio FP, Duneclift S, Atkinson RW, Cook DG. Use of alternative medicines in a multi ethnic population. Ethnicity & Disease 2001; 11:11-18.

Cook DG, Cappuccio FP, Atkinson RW, Wicks PD, Chitolie A, Nakandakare ER, Sagnella GA, Humphries SE. Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene. Am J Epidemiol 2001; 153:799-806.

Davey G, Cook DG, McKeigue P. A rebuttal--the Rsal polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training. Thromb Haemost 2001; 85:188.

De Wilde S, Carey IM, Richards N, Hilton SR, Cook DG. Do children who become autistic consult more often after MMR vaccination? Br J Gen Pract 2001; 51:226-227.

Dong YB, Zhu HD, Baker EH, Sagnella GA, MacGregor GA, Carter ND, Wicks PD, Cook DG, Cappuccio FP. T594M and G442V polymorphisms of the sodium channel b subunit and hypertension in a black population. J Hum Hypert 2001; 15:425-430.

Shah S, Cook DG. Inequalities in the treatment and control of hypertension: age, social isolation and lifestyle are more important than economic circumstances. J Hypertens 2001; 19:1333-1340.

Shah S, Harris TJ, Rink E, De Wilde S, Victor CR, Cook DG. Do income questions and seeking consent to link medical records reduce survey response rates? A randomised controlled trial among older people. Br J Gen Pract 2001; 51:223-225.

Shah S, Harris TJ, Cook DG. Differences in hormone replacement therapy use by social class, region and psychological symptoms. BJOG 2001; 108:269-275.

Taylor SJ, Whincup PH, Hindmarsh PC, Lampe F, Odoki K, Cook DG. Performance of a new pubertal self-assessment questionnaire: a preliminary study. Paediatr Perinat Epidemiol 2001; 15:88-94.

Waterworth DM, Talmud PJ, Humphries SE, Wicks PD, Sagnella GA, Strazzullo P, Alberti KG, Cook DG, Cappuccio FP. Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups. Diabetologia 2001; 44:245-248.

Whincup PH, Gilg JA, Odoki K, Taylor SJ, Cook DG. Age of menarche in contemporary British teenagers: survey of girls born between 1982 and 1986. BMJ 2001; 322:1095-1096

Full list of division publications

 

Research Grants 2001-2007

2001-7CompuFile Ltd. £25,000 annually to “Develop and exploit the Doctors Independent Network for Research” (Cook DG, Hilton SR)

2007British Heart Foundation£145,000 to study “Passive smoking, cardiovascular disease and Type 2 diabetes: prospective studies in older men and women” (Whincup PH, Wannametthee SG, Ebrahim SB, Cook DG)

2007British Heart Foundation £228,915 to study “Early markers of vascular disease in British children of South Asian, African-Caribbean and white European origin” (Whincup PH, Deanfield JE, Cook DG, Owen CG)

2006British Heart Foundation £70,000 To study “Contributions of physical activity fitness to emerging differences incardiovascular risk: a study in children” (Whincup PH, Cook DG, Ekelund U)

2006National Prevention Research Initiative £267,863 to study “Early emergence of ethnic differences in chronic disease risk: the contributions of diet and physical activity” (Whincup PH, Cook DG, Ekelund U, Stephen A)

2006British Diabetic Association £77,817 to study “Early life exposures and risk of diabetes: building a systematic review of the evidence” (Whincup PH, Owen C, Cook DG)

2006Health Effects Institute, US. For “The LEZ study. The introduction of the London Low Emission Zone (LEZ) and its impact on air quality & health” Joint project between SGUL & Kings.$112,959 Work package 5 to be held at SGUL “Evaluation of impact of LEZ on morbidity indicated by the use of family physician: development of methodology” (Anderson HR, Cook DG, Atkinson R)

2006Thames Valley Primary Care Research Partnership Start-up Grant. £23,500 for “Assessment of customary physical activity levels in older community dwelling primary care patients: a comparison of objective and subjective measures and an exploration of the determinants of physical activity in this age group” (Harris T, Cook DG, Victor C)

2005-6Pfizer Ltd. £96,000 to study “Variations in the treatment and management of glaucoma in England and possible side effects of therapy” (Cook DG, Owen C, Carey IM, DeWilde S, Wormwald R, Whincup PH)

2005BUPA Foundation 2004 Theme Funding £187,442 for “Exploiting a large primary care database with post-code linkage of socio-economic data for surveillance of disease incidence and equity of health care provision” (Cook DG, Strachan DP, Hilton SR)

2004-5AstraZeneca Ltd. £58,400 to study ”Equity of access to effective anticoagulation - what factors influence warfarin prescribing in patients with atrial fibrillation?” (Cook DG, Carey IM, DeWilde S)

2004Department of Health. £19,830 to produce a report on “The influence of maternal, fetal and child nutrition on the development of disease later in life: a synthesis of the evidence and implications for policy” (Owen C, Williams T, Whincup PH, Cook DG)

2004British Heart Foundation £153,163 To study “Early life exposures and coronary heart disease risk: building a systematic framework of observational evidence” (Whincup PH, Cook DG)

2003Wellcome Trust. £750,000 to study “Ethnicity and Cardiovascular Risk Factors: a study in Children”. (Whincup PH, Cook DG)

2002BUPA Foundation £33,000 to study “Longitudinal study of changes in depression, disability, social circumstances and health service use among older people in primary care” (Harris T, Cook DG, Victor CR)

2001Surgeon General. $24,000 to “Review the effects of ETS on children's respiratory health for the 2003 Surgeon General's Report. (Cook DG, Strachan DP)

2001Wellcome Trust. £200,000 to study “Individual and practice variations in the management and outcome of common diseases of childhood: releasing the untapped potential of computerised primary care databases”. (Cook DG, Strachan DP, Hilton

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