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Analytical Unit

The Analytical Unit is a research and service laboratory within Professor John Camm’s Division of Cardiac & Vascular Sciences.

The laboratory is accredited by the Department of Health as a GLP (Good Laboratory Practice) compliant facility.

We provide specialist analytical services for:

  • basic research studies
  • drug development
  • the diagnosis and treatment of disease

We measure drugs and endogenous compounds, using a wide variety of chromatographic and immunoassay assay techniques. Our analytical facilities include:

  • 2 Sciex API 2000 and 2 API 4000 HPLC systems with mass-spectrometric detection
  • GC/MS - using Hewlett Packard & Shimadzu GLC systems with EI & CI mass-selective detectors

Our Services

We perform bioanalytics for:

  • Grant-funded research studies
  • Higher Degree projects
  • Pre-clinical studies
  • Phase I clinical trials units
  • Multicentre clinical trials
  • Manufacturers of diagnostic devices
  • Hospitallaboratories world-wide
  • Pathologists, Coroners & Solicitors

The Unit has a close relationship with the on-site Phase I Clinical Trials Unit - Richmond Pharmacology

Core functions:

  • Teaching analytical techniques
  • Assay development
  • Assay validation
  • Proficiencytesting
  • Forensic toxicology screening
  • Tablet identification
  • Expert opinions on:
    Drug toxicity
    Drugpharmacokinetics
  • Legal cases involvingdrugs
  • Statistical analysis of study data

Contact details:

+44 (0)20 8767 9686
e-mail: dholt@sgul.ac.uk

Professor David W. Holt

Director:

Professor David W. Holt
BSc, PhD, DSc (Med), EurClin Chem, FESC, FRCPath

Professor Holt is a clinical biochemist with over 34 years’ experience in the measurement of drugs as a guide to therapy. He is Director of the Unit and Professor of Bioanalytics. He has devoted his research career to the study of the clinical toxicology of a wide variety of drugs, principally cardiac antiarrhythmics and immunosuppressive drugs used following organ transplantation. Professor Holt is the author of over 300 publications in peer reviewed journals or invited contributions to books. He is President of the International Association of Therapeutic Drug Monitoring & Clinical Toxicology.

Current Research Interests:

  • Biomarkers of CVS disease
  • Impact of pharmacogenetics on drug pharmacokinetics
    Phenotypic markers of drug metabolism
  • Pharmacodynamic markers of immunosuppressive drug effect
  • Characterisation of certified reference materials
  • Detection of drug-facilitated crime
  • Entomotoxicology
 
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