EPOR sghms10012 EPOR erythropoietin receptor (EPOR) ENSG00000105532 CD80 sghms10066 CD28LG; CD28LG1; CD80/B7-1 CD28 ligand (CD28LG ); T-lymphocyte activation CD80 antigen precursor; activation B7-1 antigen; BB1; LAB7 involved in the costimulatory signal essential for t lymphocytes activation. t cell proliferation and cytokine production is induced by the binding of cd28 or ctla-4 to this receptor. ENSG00000121594 IL6 sghms10085 BSF-2; IFNB2 interleukin-6 precursor (IL-6); B-cell stimulatory factor 2 (BSF-2); interferon beta-2 (IFNB2); hybridoma growth factor ENSG00000136244 CASP2 sghms10118 "ICH1, NEDD2; caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2)" Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH-1L/1S). involved in the activation cascade of caspases responsible for apoptosis execution. mightfunction by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. ENSG00000106144 CCR1 sghms1014 HM145; RANTES R; CCR1; CKR1; CMKR1 CC chemokine receptor type 1 (CC CKR1; CCR 1); macrophage inflammatory protein 1 alpha receptor (MIP1alpha R); RANTES R; LD78 receptor; CMKBR1 "receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1 delta, rantes, and mcp-3 and, less efficiently, to mip-1- beta or mcp-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. responsible for affecting stem cell proliferation." ENSG00000121808 CCR3 sghms1020 CMKBR3; CC-CKR-3; chemokine (C-C motif) receptor 3 CC chemokine receptor type 3 (CMKBR3; CCCKR3; CCR3); eosinophil eotaxin receptor " receptor for a c-c type chemokine. binds to eotaxin, eotaxin-3, mcp-3, mcp-4, rantes and mip-1 delta. subsequently transduces a signal by increasing the intracellular calcium ions level." ENSG00000121809 IGF1R sghms10235 JTK13 insulin-like growth factor I receptor (IGF1R) ENSG00000070207 IGF1R sghms10245 JTK13 insulin-like growth factor I receptor (IGF1R) ENSG00000070207 DAP3 sghms10356 Death-associated protein 3 ionizing radiation resistance-conferring protein + death-associated protein 3 (DAP3) ENSG00000116570 IFNAR2 sghms1050 IFNABR interferon-alpha/beta receptor beta subunit precursor (IFN-alpha-R); type I interferon receptor (IFN-R) ENSG00000004372 RELA sghms10618 NFKB3; REL nuclear factor kappa-B DNA binding subunit (NF-kappaB; NFKB) ENSG00000110192 IL2 sghms10628 IL-2 interleukin-2 precursor (IL-2); T-cell growth factor (TCGF) ENSG00000109471 IFNAR2 sghms1077 IFNABR interferon-alpha/beta receptor beta subunit precursor (IFN-alpha-R); type I interferon receptor (IFN-R) ENSG00000004372 DDIT3 sghms10849 CHOP10; CHOP; GADD153 growth arrest & DNA-damage-inducible protein 153 (GADD153); DNA-damage-inducible transcript 3 (DDIT3); C/EBP homologous protein (CHOP) ENSG00000123301 CCNG2 sghms10947 cyclin G2 cyclin G2 (CCNG2) may play a role in growth regulation and in negative regulation of cell cycle progesssion. activated by actinomycin-d induced dna damage. ENSG00000138764 IL10 sghms10962 IL-10; CSIF; TGIF interleukin-10 precursor (IL-10); cytokine synthesis inhibitory factor (CSIF) ENSG00000136634 ITGB3 sghms10981 GP3A; CD61 "Homo sapiens integrin beta 3 subunit gene, promote," ENSG00000056345 PAK2 sghms11043 hPAK65; p21 (CDKN1A)-activated kinase 2 p21-activated kinase gamma (PAK-gamma; PAK2); PAK65; S6/H4 kinase ; (EC 2.7.1.-) ENSG00000103850 CXCR4 sghms11069 HM89; NPY3R; LESTR; NPYY3R; fusin; NPYY3 stromal cell derived factor 1 receptor (SDF1 receptor); fusin; CXCR4; leukocyte-derived seven transmembrane domain receptor (LESTR); LCR1 ENSG00000121966 IFNAR2 sghms1108 IFNABR interferon-alpha/beta receptor beta subunit precursor (IFN-alpha-R); type I interferon receptor (IFN-R) ENSG00000004372 TRIP sghms11080 TRAFF interacting protein; hTRIP TRAF-interacting protein (hTRIP) ENSG00000114323 TRAF6 sghms11222 TNF receptor-associated factor 6 "TRAF6, PUTATIVE INTERLEUKIN 1 SIGNAL TRANSDUCER" ENSG00000135389 EIF2B1 sghms11261 EIF2B; eIF-2B; EIF2Balpha; EIF2S2 translation initiation factor EIF-2B alpha subunit; EIF-2B GDP-GTP exchange factor ENSG00000111361 IL1A sghms11364 IL1 interleukin-1 alpha precursor (IL-1 alpha; IL1A); hematopoietin-1 ENSG00000115008 PTK2 sghms11439 "FAK1, FAK; FADK; STK2" "Homo sapiens focal adhesion kinase mRNA, FAK1; pro; EC 2.7.1.112" ENSG00000069111 IL12A sghms11552 NKSF1; CLMF interleukin-12 alpha subunit precursor (IL-12A); cytotoxic lymphocyte maturation factor 35-kDa subunit (CLMF p35); NK cell stimulatory factor subunit 1 (NKSF1) ENSG00000113803 MDM2 sghms11588 p53-associated protein mdm2 protein; p53-associated protein + mdm2-A + mdm2-C; EC 6.3.2.- ENSG00000059102 MDM2 sghms11594 p53-associated protein mdm2 protein; p53-associated protein + mdm2-A + mdm2-C; EC 6.3.2.- ENSG00000059102 MDM2 sghms11624 p53-associated protein mdm2 protein; p53-associated protein + mdm2-A + mdm2-C; EC 6.3.2.- ENSG00000059102 PIG10 sghms11667 ENC1; NRPB; NRP/B PIG10 ENSG00000113131 ITGAX sghms11700 CD11C "leukocyte adhesion glycoprotein p150, 95 alpha subunit precursor; leukocyte adhesion receptor p150, 95; CD11C antigen; leu-M5; integrin alpha X (ITGAX)" ENSG00000103250 IFNAR1 sghms1180 IFNAR; IFRC interferon-alpha/beta receptor alpha subunit precursor (IFN-alpha receptor; IFNAR) ENSG00000099543 CCNA2 sghms11821 CCNA2; CCN1; cyclin A G2/mitotic-specific cyclin A (CCNA; CCN1) essential for the control of the cell cycle at the g1/s (start) and the g2/m (mitosis) transitions. ENSG00000138734 BAX sghms11895 BCL2-associated X protein "apoptosis regulator bax, BCL2-associated X protein" "BAXA accelerates programed cell death by binding to, and antagonizing the apoptosis. repressor bcl-2 or its adenovirus homolog e1b 19k protein. induces the release of cytochrome c,. activation of caspase-3, and thereby apoptosis. BAXB: accelerates programed cell death by binding to, and antagonizing the apoptosis repressor bcl-2 or its adenovirus homolog e1b 19k protein." ENSG00000087088 BAX sghms11919 BCL2-associated X protein "apoptosis regulator bax, BCL2-associated X protein" "BAXA accelerates programed cell death by binding to, and antagonizing the apoptosis. repressor bcl-2 or its adenovirus homolog e1b 19k protein. induces the release of cytochrome c,. activation of caspase-3, and thereby apoptosis. BAXB: accelerates programed cell death by binding to, and antagonizing the apoptosis repressor bcl-2 or its adenovirus homolog e1b 19k protein." ENSG00000087088 CDK5R2 sghms12025 p39;NCK5AI cyclin-dependent kinase 5 activator isoform p39I precursor (CDK5 activator; NCK5AI) ENSG00000135927 TNFRSF10B sghms12038 " TNFRSF10B, DR5; KILLER; TRAIL-R2; RANCE-R; TRICK2A; TRICK2B; TNFRS" death receptor 5 (DR5); cytotoxic TRAIL receptor 2 (TRICK2A); TNFRSF10B ENSG00000120889 LAG3 sghms12171 FDC lymphocyte activation gene-3 protein precursor (LAG-3); FDC protein ENSG00000089692 PPP3CA sghms12231 CCN1; CNA1; PPP2B; CALNA; CALN "cyclin I, SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ISOFORM EC 3.1.3.16 CALMODULIN DEPENDENT CALCINEURIN A SUBUNIT, ISOFORM CATALYTIC SUBUNIT" ENSG00000138814 CASP3 sghms12247 "CPP32; apopain; CPP32B; YAMA; caspase 3, apoptosis-related cysteine protease" caspase-3 (CASP-3); apopain precursor; cysteine protease CPP32; YAMA protein; SREBP cleavage activity 1; SCA-1; (EC 3.4.22.-) involved in the activation cascade of caspases responsible for apoptosis execution. at the onset of apoptosis it proteolytically cleaves poly(adp-ribose) polymerase (parp) at a 216-asp -gly-217 bond. cleaves and activates sterol regulatory element binding proteins (srebps) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. cleaves and ENSG00000129176 NOS2A sghms12258 type II NOS; hepatocyte NOS (HEP-NOS); NOS2; NOS2A; INOS "(inducible, hepatocyte) nitric oxide synthase (INOS); type II NOS; hepatocyte NOS (HEP-NOS); (EC 1.14.13.39)" ENSG00000007171 NOS2A sghms12434 type II NOS; hepatocyte NOS (HEP-NOS); NOS2; NOS2A; INOS "(inducible, hepatocyte) nitric oxide synthase (INOS); type II NOS; hepatocyte NOS (HEP-NOS); (EC 1.14.13.39)" ENSG00000007171 NOS3 sghms1246 ECNOS; ENOS "Human nitric oxide synthase mRNA, CNOS; (EC 1.14.13.39)" ENSG00000106601 NOS2A sghms12468 type II NOS; hepatocyte NOS (HEP-NOS); NOS2; NOS2A; INOS "(inducible, hepatocyte) nitric oxide synthase (INOS); type II NOS; hepatocyte NOS (HEP-NOS); (EC 1.14.13.39)" ENSG00000007171 DFF45 sghms12520 DFF-45; DFF1; DFFA; ICAD; ICAD-S DNA fragmentation factor 45 (DFF45) ENSG00000075092 DFF45 sghms12525 DFF-45; DFF1; DFFA; ICAD; ICAD-S DNA fragmentation factor 45 (DFF45) ENSG00000075092 PRF1 sghms12570 PFP perforin 1 (P1); lymphocyte pore forming protein (PFP); cytolysin; PRF1 ENSG00000122903 CDK9 sghms12619 PITALRE; CDC2L4; cycin-dependant kinase 9; TAK; C-2k cell division protein kinase 9 (CDK9); serine/threonine protein kinase PITALRE ENSG00000106988 ITGB2 sghms12700 LYAM1; CD18; LFA-1; MF17 "cell surface adhesion glycoproteins LFA-1/CR3/p150,95 beta-subunit precursor; LYAM1; integrin beta 2 (ITGB2); CD18 antigen; complement receptor C3 beta subunit" ENSG00000060864 CDK8 sghms12755 K35 cell division protein kinase 8 (CDK8); protein kinase K35; (EC 2.7.1.-) ENSG00000132964 CCND3 sghms12817 cyclin D3 G1/S-specific cyclin D3 (CCND3) essential for the control of the cell cycle at the g1/s (start) transition. interacts with the cdk4 and cdk6 protein kinases to form a serine/threonine kinase holoenzyme complex the cyclin subunit imparts substrate specificity to the complex. ENSG00000112576 BAG1 sghms12823 BCL-2 binding athanogene-1; BAG1 BCL-2 binding athanogene-1 (BAG-1); glucocorticoid receptor-associated protein RAP46 inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic ENSG00000107262 EIF2A sghms12977 EIF2-A; EIF2S1 translation initiation factor eIF-2 alpha subunit ENSG00000134001 TNFRSF6 sghms13034 FAS; fasL receptor; APT1; APO-1; CD95; FAS1 fasL receptor; apoptosis-mediating surface antigen fas; APO-1 antigen; CD95 antigen; slpice variants ENSG00000026103 TNFRSF6 sghms13080 FAS; fasL receptor; APT1; APO-1; CD95; FAS1 fasL receptor; apoptosis-mediating surface antigen fas; APO-1 antigen; CD95 antigen; slpice variants ENSG00000026103 TNFRSF6 sghms13085 FAS; fasL receptor; APT1; APO-1; CD95; FAS1 fasL receptor; apoptosis-mediating surface antigen fas; APO-1 antigen; CD95 antigen; slpice variants ENSG00000026103 VCAM1 sghms13137 VCAM-1 "Human vascular cell adhesion molecule 1 mRNA,vascu VCAM1" ENSG00000117642 CLK3 sghms13155 CLK 3 CDC-like kinase 3 (CLK3); (EC 2.7.1.-) ENSG00000138618 RPS6KA1 sghms13164 S6KII-alpha 1; RSK; HU-1; RSK1 ribosomal protein S6 kinase II alpha 1 (S6KII-alpha 1); ribosomal S6 kinase 1 (RSK1); (EC 2.7.1.-) ENSG00000117676 TNFSF5 sghms13178 CD40-L; CD40LG; ENSG00000102245 CD2 sghms13223 CD2 antigen T-cell surface CD2 antigen precursor; T-cell surface antigen T11/leu-5; LFA-2; LFA-3 receptor; erythrocyte receptor; rosette receptor "interacts with lymphocyte function-associated antigen (lfa-3/cd58) and cd59 to mediate adhesion between t cells and other cell types. cd2 is implicated in the triggerring of t cells, the cytoplasmic domain is implicated in the signaling function." ENSG00000116824 GADD45A sghms13228 gadd45; DDITI growth arrest & DNA-damage-inducible protein (GADD45); DNA-damage-inducible transcript 1 (DDIT1) ENSG00000116717 VEGF sghms13275 VEGFA vascular endothelial growth factor precursor (VEGF); vascular permeability factor (VPF) ENSG00000112715 VEGF sghms13278 VEGFA vascular endothelial growth factor precursor (VEGF); vascular permeability factor (VPF) ENSG00000112715 TP73 sghms13350 "P73, tumor protein p73" p73 (monoallelically expressed p53-related protein) ENSG00000078900 JUNC sghms13378 JUN; JRA; RJG-9 proto-oncogene c-jun; transcription factor AP-1 ENSG00000116621 NFKB1 sghms13464 NF-kapa light polypeptide gene enhancer in B-cells 1 (p105); KBF1 ENSG00000109320 NFKB1 sghms13537 NF-kapa light polypeptide gene enhancer in B-cells 1 (p105); KBF1 ENSG00000109320 CTLA4 sghms13544 CTLA-4 cytotoxic T-lymphocyte protein 4-1 precursor (CTLA-4); CD152 antigen ENSG00000035215 TNFRSF10A sghms13548 DR4; TRAILR-1; cytotoxic ligand TRAIL receptor; APO2 cytotoxic ligand TRAIL receptor ENSG00000104689 PDCD10 sghms13667 TFAR15; apoptosis related protein 15; programed cell death 10 apoptosis-related protein TFAR15 ENSG00000114209 PDCD10 sghms13674 TFAR15; apoptosis related protein 15; programed cell death 10 apoptosis-related protein TFAR15 ENSG00000114209 CDC10 sghms13688 hCDC10; SEPT7 CDC10 protein homolog ENSG00000122545 CDC10 sghms13699 hCDC10; SEPT7 CDC10 protein homolog ENSG00000122545 CLK2 sghms13720 clk2 CDC-like kinase 2 (CLK2); (EC 2.7.1.-). ENSG00000116524 CDK5 sghms1386 CRK6; PSSLRE cyclin-dependent kinase 5 activator precursor (CDK5 activator); tau protein kinase II 23-kDa subunit; TPKII regulatory subunit; (EC 2.7.1.-) ENSG00000133563 HRB sghms13903 RIP; HIV-1 Rev binding protein; RAB; hRIP receptor interacting protein; serine/threonine protein kinase RIP transferase; serine/threonine-protein kinase ATP-binding apoptosis; cell death protein RIP ENSG00000106351 PCTK1 sghms14495 PCTGAIRE; PCTAIRE protein kinase; CRK5 serine/threonine-protein kinase PCTAIRE 1 (PCTK1); (EC 2.7.1.-) ENSG00000102225 CDC25B sghms14591 CDC25Hu2 CDC25B; CDC25HU2; M-phase inducer phosphatase 2; (EC 3.1.3.48) this protein functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity. ENSG00000101224 TRAF3 sghms14616 CRAF1; CAP-1; CD40bp; TNF receptor-associated factor 3; LMP1 CD40 receptor-associated factor 1 (CRAF1) ENSG00000131323 BIRC4 sghms14630 XIAP; API3; hILP; apoptosis inhibitor 3 baculoviral IAP repeat-containing 4 inhibitor of apoptosis protein 3 (API3; IAP3); X-linked inhibitor of apotosis protein (X-linked IAP; XIAP); IAP-like protein (HILP) apoptotic suppressor. inhibitor of caspase-3 and caspase-7. ENSG00000101966 PCNA sghms14645 PCNA1; ETL proliferating cyclic nuclear antigen (PCNA); cyclin ENSG00000132646 NFKB2 sghms14766 NF-kapa light polypeptide gene enhancer in B-cells 2 (p40/p100); LYT-10 Gene nfkb2 lyt-10 hs.73090 gdb:128804 nuclear factor of kappa light polypeptide gene enhancer in b-cells 2 (p49/p100) ENSG00000077150 NFKB2 sghms14798 NF-kapa light polypeptide gene enhancer in B-cells 2 (p40/p100); LYT-10 Gene nfkb2 lyt-10 hs.73090 gdb:128804 nuclear factor of kappa light polypeptide gene enhancer in b-cells 2 (p49/p100) ENSG00000077150 FASTK sghms1489 fast Fas-activated serine/threonine (FAST) kinase ENSG00000106589 HSP86 sghms14943 heat-shock-protein-86; HSP86-1; HSP90A; HSPC1; HSPCA; HSP89A heat shock 90-kDa protein A (HSP90A; HSPCA); HSP86 ENSG00000080824 HSP86 sghms14951 heat-shock-protein-86; HSP86-1; HSP90A; HSPC1; HSPCA; HSP89A heat shock 90-kDa protein A (HSP90A; HSPCA); HSP86 ENSG00000080824 CD44 sghms14968 CD44H; IN; MDU2; MDU3; MIC4; MC56 CD44 antigen hematopoietic form precursor (CD44H); phagocytic glycoprotein I (PGP-1); HUTCH-I; extracellular matrix receptor-III (ECMR-III); GP90 lymphocyte homing/adhesion receptor (LHR); hermes antigen "main cell surface receptor for hyaluronate. adhesion to mucosal high endothelial venule and to types i and vi collagen. probably involved in matrix adhesion, lymphocyte activation and lymph node homing. subcellular location: type i membrane protein. alternative products: many isoforms of cd44 are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. a variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. the standard cd44 is expected to be expressed in normal cells; splice variants have been found in many tumor cell lines. ." ENSG00000026508 CD44 sghms15002 CD44H; IN; MDU2; MDU3; MIC4; MC56 CD44 antigen hematopoietic form precursor (CD44H); phagocytic glycoprotein I (PGP-1); HUTCH-I; extracellular matrix receptor-III (ECMR-III); GP90 lymphocyte homing/adhesion receptor (LHR); hermes antigen "main cell surface receptor for hyaluronate. adhesion to mucosal high endothelial venule and to types i and vi collagen. probably involved in matrix adhesion, lymphocyte activation and lymph node homing. subcellular location: type i membrane protein. alternative products: many isoforms of cd44 are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. a variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. the standard cd44 is expected to be expressed in normal cells; splice variants have been found in many tumor cell lines. ." ENSG00000026508 CD44 sghms15005 CD44H; IN; MDU2; MDU3; MIC4; MC56 CD44 antigen hematopoietic form precursor (CD44H); phagocytic glycoprotein I (PGP-1); HUTCH-I; extracellular matrix receptor-III (ECMR-III); GP90 lymphocyte homing/adhesion receptor (LHR); hermes antigen "main cell surface receptor for hyaluronate. adhesion to mucosal high endothelial venule and to types i and vi collagen. probably involved in matrix adhesion, lymphocyte activation and lymph node homing. subcellular location: type i membrane protein. alternative products: many isoforms of cd44 are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. a variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. the standard cd44 is expected to be expressed in normal cells; splice variants have been found in many tumor cell lines. ." ENSG00000026508 BIK sghms15067 NBK apoptotic inducer protein; BP4; BIP1; BCL2-interacting killer (apoptosis-inducing) bcl-2 interacting killer (BIK); NBK apoptotic inducer protein; BP4; BIP1 "accelerates programed cell death. binding to the apoptosis repressors bcl-x(l), bhrf1, bcl-2 or its adenovirus homolog e1b 19k protein suppresses this death-promoting activity. does not interact with bax." ENSG00000100290 IL2RB sghms15128 IL2RB interleukin-2 receptor beta subunit precursor (IL-2 receptor beta; IL2RB); p70-75; CD122 antigen ENSG00000100385 MAP3K5 sghms15198 MEKK5; MAP/ERK kinase kinase 5; ASK1; MAPKKK5 mitogen-activated protein kinase kinase kinase 5 (MAP kinase kinase kinase 5; MAPKKK 5); (EC 2.7.1.-) ENSG00000008177 RIPK1 sghms15269 RIP; receptor (TNFRSF)-interacting serine-threonine kinase 1 receptor interacting protein; serine/threonine protein kinase RIP transferase; serine/threonine-protein kinase ATP-binding apoptosis; cell death protein RIP; (EC 2.7.1.-) ENSG00000137275 MYCL1 sghms15325 L-myc; MYCL L-myc proto-oncogene (MYCL1) ENSG00000116990 TNFRSF5 sghms15380 TRAP receptor; TNFRSF5 ; CD40LG recptor; BP50 CDW40 antigen; CD40L receptor precursor; nerve growth factor receptor-related B-lymphocyte activation molecule ENSG00000101017 FRAP1 sghms15498 FRAP; mTOR; MTOR; RAFT1 FKBP-rapamycin associated protein (FRAP); rapamycin target protein ENSG00000083420 IL14 sghms15561 IL-14; HMW-BCGF interleukin-14 precursor (IL-14); high molecular weight B-cell growth factor (HMW-BCGF) ENSG00000084647 PLA2G4A sghms15647 PLA2G4; PLA2 group IV; cPLA2 beta "phospholipase A2 grp IVAcytosolic, calcium dependant; EC 3.1.1.4" ENSG00000116711 CASP10 sghms1565 "Mch4; caspase 10, apoptosis-related cysteine protease" caspase-10 precursor (CASP10); ICE-LIKE apoptotic protease 4 (ICE-LAP4); apoptotic protease MCH4; fas-associated death domain protein; interleukin-1-beta-converting enzyme 2 (FLICE2); (EC 3.4.22.-) " involved in the activation cascade of caspases responsible for apoptosis execution. recruited to both fas- and tnfr-1 receptors in a fadd dependent manner. may participate in the granzyme b apoptotic pathways. cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. hydrolyzes the small- molecule substrates, tyr-val-ala-asp-" ENSG00000003400 IFNGR1 sghms15685 IFNGR interferon-gamma receptor (IFNR-gamma; IFNGR1); CDW119 antigen; interferon-gamma receptor alpha chain ENSG00000027697 CD3E sghms15721 "CD3E antigen, epsilon subunit; T3E; CD3" T-cell surface glycoprotein CD3 epsilon subunit precursor; T-cell surface antigen T3/leu-4 epsilon subunit (T3E) the cd3 complex mediates signal transduction. ENSG00000110329 IFNGR2 sghms15741 "AF1, IFNGT1" interferon-gamma (IFN-gamma) receptor beta subunit precursor; IFN-gamma accessory factor 1 (AF1); IFN-gamma transducer 1 (IFNGT1) ENSG00000099545 CASP10 sghms1578 "Mch4; caspase 10, apoptosis-related cysteine protease" caspase-10 precursor (CASP10); ICE-LIKE apoptotic protease 4 (ICE-LAP4); apoptotic protease MCH4; fas-associated death domain protein; interleukin-1-beta-converting enzyme 2 (FLICE2); (EC 3.4.22.-) " involved in the activation cascade of caspases responsible for apoptosis execution. recruited to both fas- and tnfr-1 receptors in a fadd dependent manner. may participate in the granzyme b apoptotic pathways. cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. hydrolyzes the small- molecule substrates, tyr-val-ala-asp-" ENSG00000003400 NCAD sghms15923 CDH2; CDHN; ZNCAD "H.sapiens NCAD gene encoding N-Cadherin (EXON1),ce" ENSG00000020186 NCAD sghms15965 CDH2; CDHN; ZNCAD "H.sapiens NCAD gene encoding N-Cadherin (EXON1),ce" ENSG00000020186 BIRC3 sghms15978 HIAP-2; cIAP2; API2; MIHC; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3 inhibitor of apoptosis protein 2 (HIAP2; IAP2) + IAP homolog B; TNFR2-TRAF signalling complex protein 2; MIHB "apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2)." ENSG00000023445 BIRC3 sghms16018 HIAP-2; cIAP2; API2; MIHC; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3 inhibitor of apoptosis protein 2 (HIAP2; IAP2) + IAP homolog B; TNFR2-TRAF signalling complex protein 2; MIHB "apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2)." ENSG00000023445 PCTK3 sghms16029 not-available serine/threonine-protein kinase PCTAIRE 3 (PCTK3) (EC 2.7.1.-) ENSG00000117266 MNK1 sghms16066 MKNK1; "Human mRNA for MNK1, MAP kinase-activated protein ; MAP kinase-interacting serine/threonine kinase 1" ENSG00000079277 TNFRSF1B sghms16072 TNFR2; TNFBR; TNFR80; TNF-R75; TNF-R-II; p75; CD120b tumor necrosis factor receptor (TNFR) + tumor necrosis factor receptor 2 (TNFR2); tumor necrosis factor binding protein 2 (TBP2) ENSG00000028137 TNFRSF1B sghms16078 TNFR2; TNFBR; TNFR80; TNF-R75; TNF-R-II; p75; CD120b tumor necrosis factor receptor (TNFR) + tumor necrosis factor receptor 2 (TNFR2); tumor necrosis factor binding protein 2 (TBP2) ENSG00000028137 CASPER sghms1609 "FLAME-1; FLAME; I-FLICE; FLIP; CFLAR; CLARP, CASH, MRIT CASP8-like; FADD-like;" casp8 and fadd-like apoptosis regulator precursor (cellular flice-likeinhibitory protein) (c-flip) (caspase-eight-related protein) (casper)(caspase-like apoptosis regulatory protein) (clarp) (mach-relatedinducer of toxicity) (mrit) (caspase homolog) (cash) (inhibitor offlice) (i-flice) (fadd-like antiapoptotic molecule 1) (flame1) (usurpin). --gene: cflar or clarp or mrit or cash. [480 amino acids; 55 kd] apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity. ENSG00000003402 TNFRSF8 sghms16115 "CD30, CD153 antigen, CD30L" CD30 ligand (CD30L); CD153 antigen ENSG00000116697 PLA2G2A sghms16122 PLA2L; PLA2B "phospholipase A2 grp IIA platlets, synovial fluid; (EC 3.1.1.4)" ENSG00000127465 CASPER sghms1615 "FLAME-1; FLAME; I-FLICE; FLIP; CFLAR; CLARP, CASH, MRIT CASP8-like; FADD-like;" casp8 and fadd-like apoptosis regulator precursor (cellular flice-likeinhibitory protein) (c-flip) (caspase-eight-related protein) (casper)(caspase-like apoptosis regulatory protein) (clarp) (mach-relatedinducer of toxicity) (mrit) (caspase homolog) (cash) (inhibitor offlice) (i-flice) (fadd-like antiapoptotic molecule 1) (flame1) (usurpin). --gene: cflar or clarp or mrit or cash. [480 amino acids; 55 kd] apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity. ENSG00000003402 CSF1 sghms16177 MCSF; CSFM macrophage-specific colony-stimulating factor (CSF-1; MCSF) ENSG00000134246 TRAP sghms16295 TRAF2; TRAP3 tumor necrosis factor type 2 receptor associated protein (TRAP3) ENSG00000127191 PTPRC sghms16339 LCA; CD45; LY5; PTPRC leukocyte common antigen precursor (L-CA); CD45 antigen; PTPRC; (EC 3.1.3.48) ENSG00000081237 ITGB1 sghms16388 integrin-beta-1-subunit; FNRB; MDF2; CD29; MSK12; GPIIA fibronectin receptor beta subunit (FNRB); integrin beta 1 (ITGB1); VLA4 beta subunit; CD29 antigen ENSG00000095803 TGFB2 sghms16439 G-TSF; TGF transforming growth factor beta2 precursor (TGF-beta2; TGFB2); glioblastoma -derived T-cell suppressor factor (G-TSF); bsc-1 cell growth inhibitor; polyergin; cetermin ENSG00000092969 BBP sghms16528 P53BP2; TP53BP2 Bcl2 and p53 binding protein Bbp/53BP2 (BBP/53BP2) impedes cell cycle progression at g2/m. binds to the central domain of p53 as well as to bcl-2. interacts with protein phosphatase 1 ENSG00000091579 IFNB1 sghms16556 IFNB; IFB; interferon beta 1 interferon-beta (IFN-beta; IFNB); fibroblast interferon ENSG00000137025 CDKL1 sghms16626 KKIALRE serine/threonine-protein kinase KKIALRE; (EC 2.7.1.-) ENSG00000100490 CGR19 sghms16644 not-available p53-dependent cell growth regulator CGR19 ENSG00000100532 IL17 sghms16657 interleukin-17; CTLA8 interleukin-17 precursor (IL-17); cytotoxic T-lymphocyte-associted antigen 8 (CTLA8) ENSG00000112115 LEPR sghms16705 0BR; leptin receptor leptin receptor precursor; obese receptor (OB receptor; OB-R) ENSG00000116681 MAPK1 sghms16828 ERK2; PRKM1; ERK; MAPK extracellular signal-regulated kinase 2 (ERK2); mitogen-activated protein kinase 2 (MAP kinase 2; MAPK 2); p42-MAPK; (EC 2.7.1.-) ENSG00000100030 MAPK1 sghms16846 ERK2; PRKM1; ERK; MAPK extracellular signal-regulated kinase 2 (ERK2); mitogen-activated protein kinase 2 (MAP kinase 2; MAPK 2); p42-MAPK; (EC 2.7.1.-) ENSG00000100030 IL10RA sghms16870 IL10R; HIL-10R interleukin 10 receptor (IL-10R) ENSG00000110324 CASP4 sghms16884 "ICErel-II; ICE(rel)II; ICH-2; TX; caspase 4, apoptosis-related cysteine protease" caspase-4 precursor (CASP4); ICH-2 protease; TX protease; ICE(REL)-II; (EC 3.4.22.-) involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1. ENSG00000137756 CDH1 sghms16951 UVO; uvomorulin; E-cadherin; DIB1; CDHE cadherin1 (CDH1); epithelial cadherin precursor (E-cadherin; CDHE); uvomorulin (UVO); CAM 120/80 cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. e-cadherin has a potent invasive suppressor role. it is also a ligand for integrin alpha- e/beta-7. ENSG00000039068 PAK1 sghms17021 ORB2; PAK2; PAKA; SHK1; p21/Cdc42/Rac1-activated kinase 1 p21-activated kinase alpha (PAK-alpha; PAK1); (EC 2.7.1.-) ENSG00000087844 PAK1 sghms17022 ORB2; PAK2; PAKA; SHK1; p21/Cdc42/Rac1-activated kinase 1 p21-activated kinase alpha (PAK-alpha; PAK1); (EC 2.7.1.-) ENSG00000087844 CASP1 sghms17056 "IL1BC, ICE; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" interleukin-1 beta convertase precursor (IL-1BC); IL-1 beta converting enzyme (ICE); p45; caspase-1 (CASP1) (EC 3.4.22.36) "thiol protease that cleaves il-1 beta between an asp and an ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. specifically inhibited by the cowpox virus crma protein" ENSG00000137752 CASP1 sghms17069 "IL1BC, ICE; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" interleukin-1 beta convertase precursor (IL-1BC); IL-1 beta converting enzyme (ICE); p45; caspase-1 (CASP1) (EC 3.4.22.36) "thiol protease that cleaves il-1 beta between an asp and an ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. specifically inhibited by the cowpox virus crma protein" ENSG00000137752 CASP1 sghms17091 "IL1BC, ICE; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" interleukin-1 beta convertase precursor (IL-1BC); IL-1 beta converting enzyme (ICE); p45; caspase-1 (CASP1) (EC 3.4.22.36) "thiol protease that cleaves il-1 beta between an asp and an ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. specifically inhibited by the cowpox virus crma protein" ENSG00000137752 HLA-C sghms17204 "HLAC; HLA-JY3; major histocompatibility complex, class I, C" HLA class I histocompatibility antigen C-4 alpha subunit (HLAC) ENSG00000137325 RB1 sghms17234 RB-1; retinoblastoma 1 retinoblastoma-associated protein (RB1); PP110; P105-RB ENSG00000023527 IRF1 sghms17253 IRF-1 interferon regulatory factor 1 (IRF1) ENSG00000125347 ABL1 sghms17296 JTK7; Abelson murine leukemia viral oncogene homologue1 "proto-oncogene tyrosine-protein kinase abl; p150; c-abl. Abelson murine leukemia viral (v-abl) oncogene homolog 1, nucleocytoplasmic shuttling protein,with a loss from the nucleus upon adhesion to fibronectin matrix, activated by certain DNA-damaging agents from ionizing radiation to alkylating agents,promoting cell cycle arrest by blocking the G/S transition-in a TP53 dependent way,regulated by ATM,requiring mitogen-activated protein kinase kinase 6 activation (MAP2K6) for inducing apoptosis,activating TP73 in a mismatch repair dependent apoptosis pathway and MAP2K6 (for CABL induced apoptosis); (EC 2.7.1.112)" ENSG00000097007 CD4 sghms17307 "CD4 antigen, T4-surface-glycoprotein-precursor" T-cell surface glycoprotein T4/leu-3; CD4 antigen accessory protein for mhc class-ii antigen/t-cell receptor interaction. may regulate t-cell activation. ENSG00000010610 KIT sghms17676 SL; SCFR proto-oncogene tyrosine-protein kinase kit; c-kit; mast/stem cell growth factor receptor precursor(SCFR); CD117 antigen; (EC 2.7.1.112) ENSG00000109237 ATM sghms17718 AT1; TPLL; AT; ATA; ATC; ATD; ATDC " T-cell prolymphocytic leukemia ATA AT1 ATDC ATC ATD T-PLL ataxia telangiectasia mutated (includes complementation groups A, C and D) AT,TPLL" " involved in signal transduction, cell cycle control and dna repair. may function as a tumor suppressor. necessary for activation of c-abl and sapk. phosphorylates p53, i kappa b-alpha, brca1, ctip, nibrin and rad9. May play a role in vesicle and/or protein transport. inhibited by wortmaninn. could play a role in t-cell development, gonad and neurological function." ENSG00000010681 ICAM2 sghms1790 ICAM-2 intercellular adhesion molecule 2 precursor (ICAM2); CD102 antigen ENSG00000108622 ATM sghms17913 AT1; TPLL; AT; ATA; ATC; ATD; ATDC " T-cell prolymphocytic leukemia ATA AT1 ATDC ATC ATD T-PLL ataxia telangiectasia mutated (includes complementation groups A, C and D) AT,TPLL" " involved in signal transduction, cell cycle control and dna repair. may function as a tumor suppressor. necessary for activation of c-abl and sapk. phosphorylates p53, i kappa b-alpha, brca1, ctip, nibrin and rad9. May play a role in vesicle and/or protein transport. inhibited by wortmaninn. could play a role in t-cell development, gonad and neurological function." ENSG00000010681 ATM sghms17991 AT1; TPLL; AT; ATA; ATC; ATD; ATDC " T-cell prolymphocytic leukemia ATA AT1 ATDC ATC ATD T-PLL ataxia telangiectasia mutated (includes complementation groups A, C and D) AT,TPLL" " involved in signal transduction, cell cycle control and dna repair. may function as a tumor suppressor. necessary for activation of c-abl and sapk. phosphorylates p53, i kappa b-alpha, brca1, ctip, nibrin and rad9. May play a role in vesicle and/or protein transport. inhibited by wortmaninn. could play a role in t-cell development, gonad and neurological function." ENSG00000010681 CCR5 sghms18032 CMKBR5; CKR-5; CC-CKR-5; CKR5 "Human CC chemokine receptor 5 (CCR5) mRNA, CDS is a single exon" "receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level. may play a role in the control of granulocytic lineage proliferation or differentiation. acts as co-receptor with cd4 for primary non- syncytium-inducing strains (nsi) (macrophage-tropic) of hiv-1 virus. it promotes env-mediated fusion of the virus." ENSG00000118080 HGFAC sghms18122 HGFA; HGAP hepatocyte growth factor activator (HGF activator); (EC 3.4.21.-) ENSG00000109758 LFA3 sghms1813 CD58 lymphocyte function-associated antigen 3 precursor (LFA3); CD58 antigen ENSG00000116815 PDGFB sghms18131 PDGFB platelet-derived growth factor B subunit precursor (PDGFB; PDGF2); bacaplermin; c-sis ENSG00000100311 PDGFB sghms18139 PDGFB platelet-derived growth factor B subunit precursor (PDGFB; PDGF2); bacaplermin; c-sis ENSG00000100311 PDGFB sghms18151 PDGFB platelet-derived growth factor B subunit precursor (PDGFB; PDGF2); bacaplermin; c-sis ENSG00000100311 HLA-DRA sghms18169 "HLA-DRA1; MHC class II, DR alpha" HLA-DR antigen-associated invariant subunit;putative-p33 ENSG00000096193 CDKN1A sghms18189 CIP1; cyclin-dependent kinase inhibitor 1A; WAF1; SDI1; PIC1; CDKN1; CAP20 cyclin-dependent kinase inhibitor 1 (CDKN1A); melanoma differentiation-associated protein 6 (MDA6); CDK-interacting protein 1 (CIP1); p53 activated fragment-1 (WAF1) ENSG00000124762 BAK1 sghms18216 CDN1; BCL2-antaonist/killer 1; BCL2L7; cell death inhibitor 1 bcl2 homologous antagonist/killer (BAK) "in the presence of an appropriate stimulus, accelerates programed cell death by binding to, and antagonizing the a repressor bcl-2 or its adenovirus homolog e1b 19k protein." ENSG00000030110 MAPK14 sghms18244 CSBP1; CSBP2; MAP kinase p38; CSPB1;PRKM14; Mxi2; PRKM15; SAPK4 mitogen-activated protein kinase p38 (MAP kinase p38); cytokine suppressive anti-inflammatory drug binding protein (CSAID binding protein; CSBP); MAX-interacting protein 2 (MXI2); (EC 2.7.1.-) ENSG00000112062 FASL sghms18288 "APTL; APT1LG1; GLD; TNFSF6, murine-T-cell-antigen-4-1B" fas antigen ligand (FASL); apoptosis antigen ligand (APTL; APT1LG1); TNFSF6 ENSG00000117560 DAXX sghms18320 DAP6; death-associated protein 6 DAXX ENSG00000007565 BAD sghms1976 bbc6; BCL2L8 BAD protein; bcl-2 binding component 6 (BBC6); bcl-2L8 "promotes cell death. successfully competes for the binding to bcl-x(l) and bcl-2, thereby affecting the level heterodimerization of both these proteins with bax. can reverse the death repressor activity of bcl-x(l), but not that of bcl-2" ENSG00000002330 PDGFRB sghms2096 CD140B antigen; PDGFR; JTK12; CSF1R platelet-derived growth factor receptor beta subunit (PDGFRB); CD140B antigen; (EC 2.7.1.112) ENSG00000113721 TNFRSF1A sghms2212 TNFR1; TNF-R; TNFAR; TNFR60; TNF-R-I; TNF-R55; p55; p55-R; CD120a tumor necrosis factor receptor 1 (TNFR1); tumor necrosis factor binding protein 1 (TBP1); CD120A antigen ENSG00000067182 LTB sghms2620 "TNFC, TNSF3, lymphotoxin B, p33" lymphotoxin-beta (LT-beta; LTB); tumor necrosis factor C (TNFC) ENSG00000096158 TNFSF2 sghms2628 TNFA; TNF; DIF tumor necrosis factor precursor (TNF-alpha; TNFA); cachectin ENSG00000111956 TNFSF1 sghms2635 TNFB; LT; LTA lymphotoxin-alpha precursor (LT-alpha); tumor necrosis factor-beta (TNF-beta; TNFB) ENSG00000111955 OSM sghms2654 oncostatin M oncostatin M (OSM) ENSG00000099985 MAPK7 sghms2712 ERK5; BMK1; PRKM7; protein kinase mitogen-activated 7 extracellular signal-regulated kinase 5 (ERK5); BMK1 kinase ENSG00000128483 IL3 sghms2725 CSF1; CSFMU; IL-3 interleukin-3 precursor (IL-3); multipotential colony-stimulating factor; hematopoietic growth factor; P-cell stimulating factor; mast-cell growth factor (MCGF) ENSG00000072662 CSF2 sghms2728 GMCSF; CSFGM granulocyte-macrophage colony stimulating factor (GM-CSF); CSF2 ENSG00000113432 IL4R sghms2765 IL4RA; IL-4R-alpha interleukin-4 receptor alpha subunit precursor (IL-4R-alpha; IL4R); CD124 antigen ENSG00000077238 CDC25C sghms2877 CDC25Hs-ORF; CDC25 CDC25C; M-phase inducer phosphatase 3 ENSG00000112987 EIF3 sghms2900 eIF3; EIF-3 beta eukaryotic translation initiation factor 3 beta subunit (EIF-3 beta); EIF3 P116 ENSG00000106263 CLK1 sghms3041 CLK; CMK3; RCK2; CDC-like kinase CDC-like kinase 1 (CLK1); (EC 2.7.1.-) ENSG00000013441 CLK1 sghms3060 CLK; CMK3; RCK2; CDC-like kinase CDC-like kinase 1 (CLK1); (EC 2.7.1.-) ENSG00000013441 PDPK1 sghms3076 PkB kinase; PDH; ; Homo sapiens mRNA for PkB kinase ENSG00000103348 MAPK12 sghms3308 ERK6; SAPK3; PRKM12; p38gamma extracellular signal-regulated kinase 6 (ERK6); stress-activated protein kinase-3; mitogen-activated protein kinase p38 gamma; (MAP kinase p38 gamma); (EC 2.7.1.-) ENSG00000073196 MAPK11 sghms3347 SAPK2; PRKM11; p38-2; p38beta; protein kinase mitogen activated mitogen-activated protein kinase P38 beta (MAP kinase P38 beta); stress-activated protein kinase 2 (SAPK2); (EC 2.7.1.-) ENSG00000092984 CDK4 sghms3461 "PSK-J3, cyclin dependant kinase 4" cell division protein kinase 4; cyclin-dependent kinase 4 (CDK4); PSK-J3; (EC 2.7.1.-) ENSG00000135446 CDKN2A sghms3477 CDK4I; CDKN2; MLM; P16; INK4; MTS1; CMM2 cyclin-dependent kinase 4 inhibitor (CDK4I; CDKN2); p16-INK4; multiple tumor suppressor 1 (MTS1) ENSG00000120245 CDKN2B sghms3489 P15; MTS2; INK4B; INK4 cyclin-dependent kinase 4 inhibitor B (CDKN2B); p14-INK4B; multiple tumor suppressor 2 (MTS2) ENSG00000107083 CDK6 sghms3515 CRK2; PLSTRE cell division protein kinase 6 (CDK6); serine/threonine protein kinase PLSTIRE; (EC 2.7.1.-) ENSG00000105810 ITGAL sghms3666 LFA-1; CD11A; A-635H12.1 leukocyte adhesion glycoprotein LFA-1 alpha subunit precursor; leukocyte function-associated molecule 1 alpha chain; CD11A antigen; integrin alpha L (ITGAL) ENSG00000005844 MET sghms3691 HGFR; HGF-SF receptor; C-MET met proto-oncogene; hepatocyte growth factor receptor precursor (HGF-SF receptor); (EC 2.7.1.112) ENSG00000105976 MAP2K6 sghms3701 MKK6; PRKMK6; MEK6; SAPKK3 dual-specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6; MAPKK 6; MKK6); MAPK/ERK kinase 6; SAPKK3; (EC 2.7.1.-) ENSG00000108984 NIK sghms3738 FTDCR1B; HSNIK; MAP3K14 NIK serine/threonine protein kinase; (EC 2.7.1.37) ENSG00000006062 PLA2G1B sghms3797 "PLA2; PPLA2; PLA2A; phospholipase A2, group IB" phospholipase A2 grp IB pancreas; (EC 3.1.1.4) ENSG00000111768 IL4 sghms3833 IL-4 interleukin-4 precursor (IL-4); B-cell stimulatory factor 1 (BSF-1); lymphocyte stimulatory factor 1 ENSG00000113520 IL13 sghms3842 IL-13; NC30 interleukin-13 precursor (IL-13); NC30 ENSG00000131433 IL5 sghms3865 IL-5 interleukin-5 precursor (IL-5); T-cell replacing factor (TRF); eosinophil differentiation factor; B-cell differentiation factor I ENSG00000113525 CASP6 sghms3903 "MCH2; ced-3; ICE; caspase 6, apoptosis-related cysteine protease" caspase-6 precursor (CASP6); cysteine protease MCH2 isoforms alpha + beta; (EC 3.4.22.-) " involved in the activation cascade of caspases responsible for apoptosis execution. cleaves poly (adp-ribose) polymerase in vitro, as well as lamins. overexpression promotes programed cell death." ENSG00000138794 IL6ST sghms3952 GP130; IL-6R-beta interleukin-6 receptor beta subunit precursor (IL-6R-beta; interleukin-6 signal transducer (IL6ST); membrane glycoprotein 130 (GP130); oncostatin M receptor; CDW130 antigen ENSG00000134352 HSP40 sghms3967 HSFP1; HDJ1; DNAJ1 heat-shock protein 40 (HSP40); similar-to-PIR-Accession-Number-JN0912 ENSG00000105016 PLK sghms4045 PLK1; polo-like kinase serine/threonine-protein kinase PLK1 (STPK13); (EC 2.7.1.-) ENSG00000083092 CASP9 sghms4114 Mch6; APAF3; ICE-LAP6 "caspase-9 precursor (CASP9); ICE-like apoptotic protease 6 (ICE-LAP6); apoptotic protease MCH6; apoptotic protease activating factor 3 (APAF3), (EC 3.4.22.-)" involved in the activation cascade of caspases responsible for apoptosis execution. binding of caspase-9 to apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. proteolytically cleaves poly(adp-ribose) polymerase (parp). the short isoform lacks activity is an dominant-negative inhibitor of caspase-9. ENST00000255256 TANK sghms4270 I-TRAF; TRAF2 TRAF-interacting protein (I-TRAF) + TRAF family member-associated NF-kappaB activator TANK ENSG00000082436 TNFAIP6 sghms4295 TSG6; PS4; TNFIP6 tumor necrosis factor-inducible protein TSG-6; hyaluronate-binding protein ENSG00000123610 CCNG1 sghms4349 CYCG1; CCNG G2/mitotic-specific cyclin G1 (CCNG1; CYCG1) may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity). ENSG00000113328 TNFSF7 sghms4540 TNFSF7; CD70; CD27L; CD27LG CD27 ligand (CD27LG); CD70 antigen binds to the cd27 receptor. plays a role in t cell activation. induces the proliferation of costimulated t cells and enhances the generation of cytolytic t cells. ENSG00000125726 CCNE1 sghms4580 "CCNE, cyclin E" G1/S-specific cyclin E (CCNE) essential for the control of the cell cycle at the g1/s (start) transition. iinteracts with a member of the cdk2/cdk protein kinases to form a serine/threonine kinase holoenzyme complex. the cyclin subunit imparts substrate specificity to the complex. interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. ENSG00000105173 FCER2 sghms4588 IGEBF; FCER2A; FCE2; CD23; CD23A low-affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII; FcER2); lymphocyte IGE receptor; CD23 antigen; BLAST-2; immunoglobulin E-binding factor (IGEBF) ENSG00000104921 IFNG sghms4611 IFNG; immune interferon interferon gamma precursor (IFN-gamma; IFNG); immune interferon ENSG00000111537 PIG7 sghms4647 LITAF; LPS induced TNF-alpha factor PIG7 ENSG00000103329 DAPK1 sghms4678 DAP-kinase death-associated protein kinase 1 (DAP kinase 1; DAPK1) ENSG00000099095 PIG12 sghms4702 MGST1L1; MGST-IV PIG12 ENSG00000107101 PIG3 sghms4737 quinone oxoreductase homologue PIG3 ENSG00000115129 ACTB sghms4841 beta-actin cytoplasmic beta-actin (ACTB) has two psuedogenes actins are highly conserved proteins that are involved in various types of cell motility and are ENSG00000075624 GSK3A sghms4866 GSK3 alpha glycogen synthase kinase 3 alpha; (EC 2.7.1.37) ENSG00000105723 EGFR sghms5010 ErbB1-S; ERBB1; ERBB; CG10079; DER; DMHD-33; TOP epidermal growth factor receptor (EGFR); IGFBP1; EC 2.7.1.112 ENSG00000069739 TNFSF10 sghms5053 TRAIL; TRAIL-PEN; TNF-related apoptosis inducing ligand; APO-2L TNF-related apoptosis inducing ligand (TRAIL); APO-2 ligand (APO2L) ENSG00000121858 TNFSF10 sghms5062 TRAIL; TRAIL-PEN; TNF-related apoptosis inducing ligand; APO-2L TNF-related apoptosis inducing ligand (TRAIL); APO-2 ligand (APO2L) ENSG00000121858 IL1R2 sghms5089 IL-1R2; IL1RB interleukin-1 receptor type II precursor (IL-1R2); IL-1R-beta ENSG00000115590 CASP8 sghms5112 "MCH5; FLICE; MACH; caspase 8, apoptosis-related cysteine protease" caspase-8 precursor (CASP8); ICE-LIKE apoptotic protease 5; MORT1-associated CED-3 homolog (MACH); FADD-homologous ICE/CED-3-like protease; FADD-like ICE (FLICE); MCH5; CAP4; (EC 3.4.22.) "most upstream protease of the activation cascade of caspases responsible for the fas-receptor mediated (cd95) and tnfr-1 induced cell death. binding to the adaptor molecule fadd recruits it to either receptors. the resulting aggregate called the death-inducing signaling complex (disc) performs flice/mach proteolytic activation. the active dimeric enzyme is then liberated from the disc and free to activate downstream apoptotic proteases. proteolytic fragments of the n-terminal propeptide (termed cap3, cap5 and cap6) are likely retained in the disc. cleaves and activates caspase-3, -4, -6, -7, -9, and -10. may participate in the granzyme b apoptotic pathways. proteolytically cleaves poly(adp-ribose) polymerase (parp). hydrolyzes the small- molecule substrate, ac- asp-glu-val-asp -amc. likely target for the cowpox virus crma death inhibitory protein." ENSG00000064012 RBL2 sghms5297 retinoblastoma-like 2 retinoblastoma-like protein 2 (RBL2; RB2); 130-kDa retinoblastoma-associated protein ENSG00000103479 GAPD sghms5520 GAPDH; G3PDH liver glyceraldehyde 3-phosphate dehydrogenase (GAPDH); (EC 1.2.1.12). ENSG00000111640 BRAF sghms5706 BRAF1; RAF1B; v-raf murine sarcoma viral oncogene homolog B1 B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.1.-)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). involved in the transduction of mitogenic signals from the cell membrane to the nucleus; may play a role in the postsynaptic responses of hippocampal neuron. ENSG00000008355 HSPB1 sghms5745 HSPB27 heat shock 27-kDa protein (HSP27); stress-responsive protein 27 (SRP27); estrogen-regulated 24-kDa protein; HSPB1 ENSG00000106211 IL11 sghms5795 IL-11 interleukin-11 (IL-11); adipogenesis inhibitory factor (AGIF) ENSG00000095752 CDC25A sghms5856 cdc25M3 cell division cycle protein 25A (CDC25A); M-phase inducer phosphatase 1; (EC 3.1.3.48) "this protein functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity. dephosphorylates p33(cdk2) in complex with cyclin e, in vitro." ENSG00000114239 HSPA4 sghms5970 hsp70 RY; HSP70RY "heat shock 70-kDa protein 4 (HSP70RY), HS24/p52" ENSG00000051911 HSPA4 sghms5978 hsp70 RY; HSP70RY "heat shock 70-kDa protein 4 (HSP70RY), HS24/p52" ENSG00000051911 CSF3 sghms6065 CSFG granulocyte colony-stimulating factor precursor (G-CSF); pluripoietin; CSF3 ENSG00000108342 BIRC3 sghms6107 HIAP-2; cIAP2; API2; MIHC; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3 inhibitor of apoptosis protein 2 (HIAP2; IAP2) + IAP homolog B; TNFR2-TRAF signalling complex protein 2; MIHB "apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2)." ENSG00000023445 BIRC2 sghms6129 HIAP-1; HIAP-2; API1; MIHB; cIAP1; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2 inhibitor of apoptosis protein1 (HIAP1; API1) + IAP homolog C; TNFR2-TRAF signaling complex protein 1; MIHC "apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2)." ENSG00000110330 BIRC2 sghms6140 HIAP-1; HIAP-2; API1; MIHB; cIAP1; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2 inhibitor of apoptosis protein1 (HIAP1; API1) + IAP homolog C; TNFR2-TRAF signaling complex protein 1; MIHC "apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2)." ENSG00000110330 ITGA4 sghms6185 CD49D; VLA-4; alphaL integrin alpha 4 precursor (ITGA4); VLA4; CD49D antigen ENSG00000115232 TGFA sghms6188 TGF-Alpha transforming growth factor-alpha (TGF-alpha; TGFA); EGF-like TGF (ETGF) ENSG00000135634 RAF1 sghms6217 v-raf-1 murine leukemia viral oncogene homologue 1 C-raf proto-oncogene (RAF1); (EC 2.7.1.-) ENSG00000075993 LEP sghms6297 OB; OBS; obesity; LEPB leptin precursor; obesity factor; obese protein ENSG00000128569 CCNH sghms6359 cyclin H associated protein cyclin H (CCNH); MO15-associated protein "member of cak which activates cyclin-associated cdc2/cdk2/cdk4 by threonine phosphorylation. Its expression and activity are constant throughout the cell cycle. cak is tightly associated with a multiprotein complex tfiih, which plays a dual role in transcription and dna repair. mammalian cak contains three components: cdk7, cyclin h, and an assembly factor called mat1." ENSG00000134480 JUNB sghms6478 JUN-B jun-B ENSG00000123153 MAPKK2 sghms6494 MAP2K2; PRKMK2; MAP kinase kinase 2 dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2; MAPKK 2); ERK activator kinase 2; MAPK/ERK kinase 2 (MEK2) ENSG00000126934 ITGAV sghms6612 vitronectin-alpha-subunit; CD51 antigen; VNRA vitronectin receptor alpha subunit (VNRA); integrin alpha 5 subunit (ITGA5); CD51 antigen ENSG00000138448 ITGAV sghms6619 vitronectin-alpha-subunit; CD51 antigen; VNRA vitronectin receptor alpha subunit (VNRA); integrin alpha 5 subunit (ITGA5); CD51 antigen ENSG00000138448 CDC6 sghms6681 CDC18L; CDC18-like CDC6-related protein N/A ENSG00000094804 MAPK4 sghms6724 ERK3-related extracellular signal-regulated kinase 4 (ERK4); MAP kinase 4 (MAPK4; p63-MAPK); PRKM4; EC 2.7.1.- ENSG00000101715 EIF4E sghms6734 EIF-4E eukaryotic translation initiation factor 4E (EIF4E); mRNA cap-binding protein; EIF-4F 25-kDa subunit ENSG00000136468 TRAF5 sghms6750 TNF receptor-associated factor 5 TRAF5 ENSG00000082512 APAF1 sghms6810 apoptotic protease activating factor 1; CED4 "apoptotic protease activating factor 1 (APAF1) reannontation gives 2 ENSTs (26, 27 exons)" "participates with caspase-9 (apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. this activation requires atp." ENSG00000120868 APAF1 sghms6900 apoptotic protease activating factor 1; CED4 "apoptotic protease activating factor 1 (APAF1) reannontation gives 2 ENSTs (26, 27 exons)" "participates with caspase-9 (apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. this activation requires atp." ENSG00000120868 HSPA6 sghms7055 HSPA1L; HSP70B heat shock 70-kDa protein 6 (heat shock 70-kDa protein B) ENSG00000132191 PCTK2 sghms7073 PCTAIRE protein kinase 2 serine/threonine-protein kinase PCTAIRE 2 (PCTK2); EC 2.7.1.- ENSG00000059758 GRO2 sghms7075 MIP2-alpha; MIP2B; SCYB2; SCYB7; TGB1; THBG1; MGSA; GROG; GROB; GRO3; PPBP macrophage inflammatory protein 2 alpha (MIP2-alpha); growth-regulated protein beta (GRO-beta) ENSG00000081041 ING1 sghms7087 ING1; P24; P23 p33ING1 ENSG00000134898 IL-7 sghms7107 IL7 interleukin-7 (IL-7) ENSG00000104432 ITGB4 sghms7157 INTEGRIN BETA "Homo sapiens ITGB4 gene for integrin beta 4, 41 exons" ENSG00000073443 ITGB4 sghms7179 INTEGRIN BETA "Homo sapiens ITGB4 gene for integrin beta 4, 41 exons" ENSG00000073443 CDC2 sghms7268 CDC2-polypeptide-(CDC2)- cell division control protein 2 homolog (CDC2); p34 protein kinase; cyclin-dependent kinase 1 (CDK1); (EC 2.7.1.-) plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive carboxyl-terminus of rna polymerase ii. ENSG00000096740 CDC2 sghms7277 CDC2-polypeptide-(CDC2)- cell division control protein 2 homolog (CDC2); p34 protein kinase; cyclin-dependent kinase 1 (CDK1); (EC 2.7.1.-) plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive carboxyl-terminus of rna polymerase ii. ENSG00000096740 FCGR3A sghms7294 "CD16; FCG3; FCGR3, FCGR3B" Human low affinity IgG receptor CD16 (FcGRIII) mRN ENSG00000081717 MDMX sghms7321 MDM4 MDM2-like p53-binding protein (MDMX) ENSG00000058676 HSPA10 sghms7397 "heat shock cognate 71kD protein, HSC71, HSPA10;" heat shock cognate 71-kDa protein ENSG00000109971 IL18 sghms7454 IL-18; IGIF interleukin-18 precursor (IL-18); interferon-gamma-inducing factor (IFN-gamma-inducing factor); interleukin-1 gamma (IL-1 gamma) ENSG00000137718 MYCN sghms7481 "MYCN, NMYC" "Neuroblastoma derived v-myc homologue, proto-oncogene" ENSG00000055923 IGF1 sghms7497 IGF1A insulin-like growth factor IA precursor (IGF1A); IGFBP1; somatomedin C + insulin-like growth factor I (IGF1) ENSG00000017427 IGF1 sghms7514 IGF1A insulin-like growth factor IA precursor (IGF1A); IGFBP1; somatomedin C + insulin-like growth factor I (IGF1) ENSG00000017427 CDH5 sghms7556 "Cadherin 5,VE-cadherin (vascular endothelium) 7B4" cadherin 5 (CDH5); vascular endothelial cadherin precursor (VE-cadherin); 7B4 antigen; CD144 antigen cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. this cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. it associates with alpha-catenin forming a link to the cytoskeleton. ENSG00000103057 CRADD sghms7560 RAIDD; CASP2 and RIPK1 domain containing adaptor with death domain death domain containing protein CRADD; apoptotic adaptor molecule for caspase-2 & FasL/TNF receptor-interacting protein RIP; (EC 3.4.22.-) ENSG00000106144 MAPK3 sghms7653 ERK1; PRKM3 extracellular signal-regulated kinase 1 (ERK1; p44-ERK1); microtubule-associated protein 2 kinase; insulin-stimulated MAP2 kinase; MAP kinase 1 (MAPK1; p44-MAPK); PRKM3; (EC 2.7.1.-) ENSG00000102882 TGFB1 sghms7823 TGFB transforming growth factor-beta (TGF-beta; TGFB) ENSG00000105329 CDKN2D sghms7978 CDK-inhibitor-2D; INK4D cyclin-dependent kinase 4 inhibitor D (CDKN2D); p19-INK4D ENSG00000129355 AKT2 sghms8082 "RAC; PKB," "RAC-beta serine / threonine protein kinase (EC 2.7.1.-) (RAC-PK-beta)(Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta)." general protein kinase capable of phosphorylating several known proteins ENSG00000105221 ICAM1 sghms8101 ICAM1; CD54 intercellular adhesion molecule-1 precursor (ICAM1); major group rhinovirus receptor; CD54 antigen ENSG00000090339 GRB2 sghms8243 EGFRBP; ASH growth factor receptor-bound protein 2 (GRB2) isoform; GRB3-3; SH2/SH3 adaptor GRB2; ASH protein + epidermal growth factor receptor-bound protein 2 (EGFRBP-GRB2) ENSG00000133200 IL12B sghms8264 NKSF2; CLMF interleukin-12 beta subunit precursor (IL-12B); cytotoxic lymphocyte maturation factor 40-kDa subunit (CLMF p40); NK cell stimulatory factor subunit 2 (NKSF2) ENSG00000113302 INSR sghms8382 INSR insulin receptor precursor (INSR) ENSG00000074199 INSR sghms8432 INSR insulin receptor precursor (INSR) ENSG00000074199 INSR sghms8452 INSR insulin receptor precursor (INSR) ENSG00000074199 RPS19 sghms8629 ribosomal protein S19 40S ribosomal protein S19 (RPS19) ENSG00000105372 BCL2A1 sghms8682 GRS; HBPA1; BCL2-related A1; BFL1; BCL2L5 BCL-2-related protein A1 (BCL2A1); BFL1 protein; hemopoietic-specific early response protein; GRS protein retards apoptosis induced by il-3 deprivation. may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (by similarity). ENSG00000136375 BCL2A1 sghms8691 GRS; HBPA1; BCL2-related A1; BFL1; BCL2L5 BCL-2-related protein A1 (BCL2A1); BFL1 protein; hemopoietic-specific early response protein; GRS protein retards apoptosis induced by il-3 deprivation. may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (by similarity). ENSG00000136375 CD14 sghms8733 LPS-R; CD14 antigen monocyte differentiation CD14 antigen precursor; myeloid cell-specific leucine-rich glycoprotein; LPS receptor (LPS-R) "serves as an lps receptor controlling cell activation under physiological conditions. when lps binds to cd14 the cells become activated and release cytokines and up-regulate cell surface molecules, including adhesion" ENSG00000113113 PIG11 sghms8856 PIG11;p53 induced protein p53 induced protein ENSG00000110464 CCNB1 sghms8868 CCNB; CCN-2; CCNB; CYCB; CYCB1 G2/mitotic-specific cyclin B1 (CCNB1) essential for the control of the cell cycle at the g2/m (mitosis) transition. ENSG00000134057 CCND1 sghms8888 cyclin D1 (PRAD1: parathyroid adenomatosis 1) PRAD1; U21B31; D11S287E; BCL1; CYL-1 G1/S-specific cyclin D1 (CCND1); cyclin PRAD1; bcl-1 oncogene essential for the control of the cell cycle at the g1/s (start) transition. ENSG00000110092 MAPK6 sghms8916 p97MAPK; PRKM6; ERK3 extracellular signal-regulated kinase 3 (ERK3); MAP kinase 3 (MAPK3; p97-MAPK); PRKM5; (EC 2.7.1.-) ENSG00000069956 bcl2 sghms8945 bcl-2-protein; b-cell CLL/lymphoma 2 apoptosis regulator bcl2 prolongs the survival of hematopoietic cells in the absence of required growth factors and also in the presence of various stimuli inducing cellular death. bcl2 blocks apoptosis because it interferes with the activation of caspases by preventing the release of cytochrome c. might function in an antioxidant pathway to prevent apoptosis at sites of free radical generation such as mitochondria. ENSG00000119533 MEKK3 sghms9011 MAP3K3; MEKKK; MAP/ERK kinase kinase 3 MAPK/ERK kinase kinase 3 (MEK kinase 3; MEKK3); (EC 2.7.1.-) ENSG00000087997 PIK3C2B sghms9102 C2-PI3K; PI3K-C2beta Homo sapiens PI3 kinase regulatory subunit P101 mR; (EC 2.7.1.137) ENSG00000133056 MIG sghms9122 Humig; CMK; SCYB9 cytokine humig; interferon-gamma-induced monokine (MIG) ENSG00000138755 TRADD sghms9161 TNFRSF1A-associated via death domain tumor necrosis factor receptor 1-associated death domain protein (TNFR1-associated death domain protein; TRADD) ENSG00000102871 ERBB2 sghms9459 NGL; NEU; HER2 ERBB2 receptor protein-tyrosine kinase; neu proto-oncogene; c-erbB2 + HER2 receptor ENSG00000108328 MAPKK 1 sghms9575 MAP2K1; PRKMK1; MEK1; MKK1 dual-specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1; MAPKK 1; MKK1); extracellular signal-regulated kinase 1; ERK activator kinase 1 ENSG00000081684 NFATC1 sghms9598 NF-Atc; NFAT transcription factor NF-ATc ENSG00000131196 NFATC1 sghms9615 NF-Atc; NFAT transcription factor NF-ATc ENSG00000131196 PDGFRA sghms9674 PDGF-R-alpha; CD140A antigen platelet-derived growth factor receptor alpha subunit (PDGFRA); CD140A antigen; (EC 2.7.1.112) ENSG00000134853 CDK2 sghms9837 cyclin-dependent protein kinase 2 cyclin-dependent protein kinase 2 (CDK2); p33 protein kinase; (EC 2.7.1.-) "probably involved in the control of the cell cycle. interacts with cyclins a, d, or e. activity of cdk2 is maximal during s phase and g2." ENSG00000123374 TLR1 sghms9937 TIL; Toll-like receptor1 "Toll-like receptor1, TLR6" ENSG00000036158 CDKN1C sghms18363 KIP2; P57 cyclin-dependent kinase inhibitor 1C (CDKN1C); p57-KIP2 ENSG00000129757 VDR sghms18482 VitD "VITAMIN D3 RECEPTOR (VDR) (1,25-DIHYDROXYVITAMIN D3 RECEPTOR)" ENSG00000111424 FANCG sghms18657 FAG Fanconi anemia group G protein (FACG protein) (DNA-repair proteinXRCC9). ENSG00000107103 IL9 sghms18805 P40-protein-precursor; hp40 interleukin-9 precursor (IL-9); T-cell growth factor p40 ENSG00000120719 INHBA sghms18815 "Inhibin beta A, EDF" erythroid differentiation protein (EDF); inhibin beta A subunit precursor; activin beta-A subunit ENSG00000122641 TCF3 sghms18835 E2A transcription factor E2-alpha (E2A); immunoglobulin enhancer binding factor E12; transcription factor-3 (TCF3) ENSG00000071564 CD38 sghms18863 ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1)(CADPR hydrolase 1) (Lymphocyte differentiation antigen CD38) ENSG00000004468 TLR7 sghms18887 Toll-like receptor 7 ENSG00000087343 TLR8 sghms18890 Toll-like receptor 8. ENSG00000101916 STAT3 sghms18934 Member 3 of the STAT family of transcription factors; binds IL6-responsive elements in promoter of acute-phase protein genes. signal transducer and activator of transcription 3 (STAT3); acute-phase response factor (APRF) ENSG00000108777 KITLG sghms19041 Kit-1; SCF; MGF stem cell factor precursor (SCF); mast cell growth factor (MGF); c-kit ligand ENSG00000049130 IL15 sghms19056 IL15 interleukin-15 (IL-15) ENSG00000064288 ICSBP1 sghms19083 interferon consensus sequence-binding protein 1; ICSBP1; H-ISCBP interferon consensus sequence-binding protein (ICSBP) ENSG00000103208 VAV1 sghms19135 vav 1 oncogene VAV proto-oncogene. ENSG00000129992 ZNFN1A4 sghms19271 Zinc finger transcription factor Eos. ENSG00000123411 TLR9 sghms19296 Toll-like receptor 9 form B. ENSG00000126055 SOD3 sghms19362 Extracellular SOD extracellular superoxide dismutase precursor (EC-SOD; SOD3); (EC 1.15.1.1) ENSG00000109610 JAK3 sghms19441 janus kinase 3 (JAK3); leukocyte janus kinase (L-JAK); Tyrosine-protein kinase JAK3 (EC 2.7.1.112) ENSG00000105639 IL1R1 sghms19506 IL1RA; IL1RN interleukin-1 receptor antagonist protein precursor (IL-1RA; IRAP); GDB has two entries one as IL1R1 2q12-2q12 and IL1RN 2q14.2-2q14.2; ENSG00000115594 GST12 sghms19511 microsomal GST1 microsomal glutathione S-transferase 12 (GST12; MGST1) ENSG00000008394 SELPLG sghms19580 P-selectin ligand P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin Pligand) (CD162 antigen). ENSG00000110876 JUND sghms19606 jun-D jun-D ENSG00000130522 CEBPA sghms19670 C/EBP alpha CCAAT/enhancer binding protein alpha (C/EBP alpha). ENSG00000130878 GSR sghms19950 Glutathione reductase glutathione reductase (GRase; GSR; GR) ENSG00000104687 ICAM3 sghms20211 Intercellular adhesion molecule-3 precursor (ICAM-3) CDw50) (CD50antigen) (ICAM-R) ENSG00000076662 ID2 sghms20289 DNA-binding protein inhibitor ID-2. ENSG00000115738 GPX1 sghms20372 Glutathione peroxidase glutathione peroxidase (GSHPX1; GPX1) ENSG00000130152 TLR2 sghms20377 TOLL-LIKE RECEPTOR 2. ENSG00000137462 FOG2 sghms20467 Friend of GATA2 ZINC FINGER PROTEIN FOG-2. ENSG00000104396 MAPK8 sghms20498 JNK; PRKM8; protein kinase mitogen-activated 8; JNK1; SAPK1 "c-jun N-terminal kinase 1 (JNK1); JNK46, see MAPK10; Mitogen-activated protein kinase 8 (EC 2.7.1.-) (Stress-activatedprotein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46)." ENSG00000107643 MZF1 sghms20518 ZNF42 zinc finger protein 42 (ZNF42); myeloid zinc finger 1 (MZF-1) ENSG00000099326 LMO1 sghms20588 RHOMBOTIN 1; RBTN1; RHOMBOSINE; RHOM1; T-CELL TRANSLOCATION GENE 1; TTG1 Rhombotin-1 (Cysteine rich protein TTG-1) (T-cell translocation protein 1) (LIM-only protein 1) ENSG00000040201 GSTP1 sghms20623 GST3 glutathione S-transferase pi (GSTP1; GST3) ENSG00000084207 STAT1 sghms20658 Member 1 of the STAT family of transcription factors; appears to be specifically required for interferon signaling ENSG00000115415 STAT4 sghms20698 Member 4 of the STAT family of transcription factors; has a role in interleukin 12 (IL12) signal transductionsignal transducer and activator of transcription 4 (STAT4) ENSG00000138378 TLR3 sghms20720 Member of Toll-like receptor family of proteins; may interact with microbial lipoproteins ENSG00000109792 MOX2 sghms20735 "CD200, OX2" OX-2 membrane glycoprotein precursor (Fragment) ENSG00000091972 STAT5B sghms20774 Member 5B of the STAT family of transcription factors; component of IL-2 receptor signalling in peripheral blood ENSG00000049025 STAT5A sghms20906 STAT5A is a member of the family of Signal. Transducers and Activators of transcription. It was originally identified as a mammary gland factor (MGF) which binds to GAS (gamma interferon ENSG00000126561 STAT5A sghms20909 STAT5A is a member of the family of Signal. Transducers and Activators of transcription. It was originally identified as a mammary gland factor (MGF) which binds to GAS (gamma interferon ENSG00000126561 NFE2 sghms20972 "Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid-derived 2 45 kDa subunit) (P45 NF-E2) (Leucine zipper protein NF-E2)." ENSG00000123405 THPO sghms21034 TPO; MGDF Thrombopoietin precursor (Megakaryocyte colony stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand)(ML) (Megakaryocyte growth and development factor) (MGDF) ENSG00000090534 IL1B sghms21319 interleukin-1-precursor-polypeptide interleukin-1 beta precursor (IL-1 ; IL1B); catabolin ENSG00000125538 GATA2 sghms21371 endothelial transcription factor GATA2 ENSG00000123537 KLF1 sghms21389 EKLF Erythroid krueppel-like transcription factor (EKLF) (Erythroidtranscription factor) ENSG00000105610 TRX2 sghms21569 Mitochondrial thioredoxin; TXN2 Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein) ENSG00000105663 TGFB3 sghms21647 TGF-beta3 transforming growth factor-beta 3 (TGF-beta3) ENSG00000119699 FOS sghms21671 P55-C-FOS proto-oncogene protein (Cellular oncogene C-FOS) (G0S7protein). ENSG00000119606 GATA1 sghms21974 Erythroid transcription factor (GATA-1) (Eryf1) (GF-1) (NF-E1). ENSG00000102145 MYC sghms22076 MYC; c-myc; v-myc avian myelocytomatosis oncogene homologue c-myc oncogene ENSG00000127294 CSF2RB sghms22148 CSF2 receptor beta (GM) ENSG00000100368 MT-TRX sghms22155 Mitochondrial thioredoxin; TXN2 Mitochondrial thioredoxin precursor (MT-TRX). ENSG00000100348 MYB sghms22285 MYBL1 MYB proto-oncogene protein (C-MYB) ENSG00000118513 MYB sghms22304 MYBL1 MYB proto-oncogene protein (C-MYB) ENSG00000118513 CD34 sghms22327 hemopoietic progenitor cell CD34 antigen precursor ENSG00000007786 JAG1 sghms22385 Jagged-1; JAGGED1 jagged 1 (HJ1) ENSG00000101384 LMO2 sghms22404 RBTN2; TAL1 rhombotin-2 (RBTN2; RHOM2); cysteine rich protein TTG-2; T-cell translocation protein 2; LIM-only protein 2 (LMO2) ENSG00000135363 SOD2 sghms22421 Mn SOD superoxide dismutase precursor (SOD2); (EC 1.15.1.1) ENSG00000112096 SOD2 sghms22424 Mn SOD superoxide dismutase precursor (SOD2); (EC 1.15.1.1) ENSG00000112096 TAL1 sghms22529 TAL1; SCL stem cell protein (SCL); T-cell leukemia/lymphoma-5 protein (TCL5); T-cell acute lymphocytic leukemia-1 protein (TAL1) ENSG00000123468 IL8 sghms22567 LUCT; MDNCF; TSG-1; SCYB8 interleukin-8 precursor (IL-8); monocyte-derived neutrophil chemotactic factor (MDNCF); T-cell chemotactic factor; neutrophil-activating protein 1 (NAP1); lymphocyte-derived neutrophil-activating factor (LYNAP); protein 3-10C ENSG00000016395 IL2RA sghms22602 IL2R interleukin-2 receptor alpha subunit precursor (IL-2 receptor alpha subunit; IL2RA); p55; TAC antigen; CD25 ENSG00000134460 TLR4 sghms22627 Toll-like receptor Toll-like receptor 4; interacts with microbial lipoproteins; member of Toll-like receptor family of proteins ENSG00000136869 JAK2 sghms22695 Janus kinase 2 (JAK2); receptor-associated tyrosine kinase; (EC 2.7.1.112) (Janus kinase 2) ENSG00000096968 MX1 sghms22889 MXA Interferon-regulated resistance GTP-binding protein MxA (Interferon-induced protein P78) (IFI-78K) ENSG00000021111 JAK1 sghms23213 Janus kinase 1 (JAK1); Tyrosine-protein kinase JAK1 (EC 2.7.1.112) ENSG00000116666 FANCC sghms23237 FAC Fanconi anemia group C protein (FACC protein). ENSG00000107359 GATA3 sghms23261 Trans-acting T-cell specific transcription factor GATA-3. Binds to enhancer element of all four TCR genes ENSG00000107485 CSF3R sghms23307 G-CSF receptor alpha granulocyte colony stimulating factor receptor precursor (GCSF-R); CD114 antigen ENSG00000119535 HCRTR2 sghms23330 "OX2R, hypocretin (orexin) receptor 2" Orexin receptor type 2 (OX2R) (Hypocretin receptor type 2). ENSG00000137252 AKT1 sghms23395 " RAC, PKB, PRKBA, RAC-ALPHA" "AKT1; rac protein kinase alpha, ENSEMBL entry contains name for both AKT1 and related 2 AKT2 is chr 19, mouse AKT1 is called AKT2 conatains exons 1-4" ENSG00000130240 THY1 sghms23683 CD90 Thy-1 membrane glycoprotein precursor (Thy-1 antigen) (CDw90)(CD90 antigen) ENSG00000118099 DCTD sghms23696 dCMP deaminase Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase). ENSG00000129187 ETV6 sghms23700 TEL; ets variant 6 Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETStranslocation variant 6) ENSG00000111246 CSF1R sghms23746 M-CSFR; FMS macrophage colony stimulating factor I receptor precursor (CSF-1-R); fms proto-oncogene (c-fms); CD115 ENSG00000020656 CCND2 sghms23784 "CCND2, cyclin D2; CYL-2; VIN-1" G1/S-specific cyclin D2 (CCND2) + KIAK0002 ENSG00000118971 E2F1 sghms23867 RBP3; RBBP3; E2F-1 PRB-binding protein E2F1; retinoblastoma-binding protein 3 (RBBP3); retinoblastoma-associated protein 1 (RBAP1); PBR3 ENSG00000101412 TP53 sghms23892 P53; TRP53 Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoproteinp53) ENSG00000129220 IL12RB1 sghms23997 IL12RB; IL12R Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1)(Interleukin-12 receptor beta) (IL-12 receptor beta component) ENSG00000096996 CYP4F2 sghms24012 "cytochrome P450, subfamily IVF, polypeptide 2" ENSG00000105101 CYP4F2 sghms24019 "cytochrome P450, subfamily IVF, polypeptide 2" ENSG00000105101 MADCAM1 sghms24036 "MACAM1,addressin, mucosal MAdCAM-1 mucosal vascular addressin cell adhesion molecule 1" MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1 PRECURSOR MADCAM [expressed by laminar propria vascular endothelial cells; directs lympocyte entry into mucosa] ENSG00000099866 FZD5 sghms24081 Frizzled 5 frizzled 5 ENSG00000144409 HSPB3 sghms24091 HSPBL4-PEN; HSPL4; HSPL27; heart heat shock protein 27 ENSG00000145651 SELL sghms24233 "hLHRc, LNHR, LAM1, LSEL, PLNHR, LYAM1, Lyam-1, LAM-1, lymph node homing receptor, Leu-8, selectin L (lymphocyte adhesion molecule 1)" L-SELECTIN PRECURSOR (LYMPH NODE HOMING RECEPTOR) cell surface adhesion protein. mediate the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. ENSG00000117489 SELE sghms24265 "ELAM1; ESEL, selectin E (endothelial leukocyte adhesion molecule 1), ELAM" E-SELECTIN PRECURSOR expressed on cytokine induced endothelial cells and mediates their binding to leukocytes. the ligand recognized by elam-1 is sialyl-lewis x (alpha(1->3) fucosylated derivatives of polylactosamine that are found at the nonreducing termini of glycolipids) ENSG00000007908 EDN3 sghms24290 "ET3, endothelin 3" ENDOTHELIN 3 PRECURSOR ET endothelins are endothelium-derived vasoconstrictor peptides ENSG00000124205 POR sghms24324 P450 oxidoreductase NADPH-cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R) ENSG00000127948 EDN2 sghms24370 "ET2, endothelin 2" ENDOTHELIN-2 PRECURSOR (ET-2) endothelins are endothelium-derived vasoconstrictor peptides ENSG00000127129 IL2RG sghms24435 hIL-2Rg; IMD4;SCIDX1; XSCID; SCIDX; CD132 interleukin-2 receptor gamma subunit (IL-2R gamma; IL2RG); cytokine receptor common gamma chain precursor; p64 ENSG00000147168 CASP7 sghms24684 MCH3; CMH-1; ICE-LAP3 caspase-7 precursor (CASP7); ICE-like apoptotic protease 3 (ICE-LAP3); apoptotic protease MCH-3; CMH-1; (EC 3.4.22.-) ENSG00000148722 PTGER4 sghms24745 PGE; prostoglandin E receptor 4 (subtype EP4); PTGER4; PTGER2; PTGEREP2 prostaglandin E2 (PGE) receptor EP4 subtype (PTGER4; PTGER2); prostanoid EP4 receptor ENSG00000145599 EDN1 sghms24760 "ET1, endothelin 1" ENDOTHELIN-1 PRECURSOR (ET-1) endothelins are endothelium-derived vasoconstrictor peptides ENSG00000078401 ANPEP sghms24830 "alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) CD13, PEPN" aminopeptidase n (ec 3.4.11.2) (microsomal aminopeptidase) (gp150)(myeloid plasma membrane glycoprotein cd13) also serves as a receptor for human coronavirus 229e ENSG00000140532 TAC3 sghms24942 "NKB; NKNB; tachykinin 3 (neuromedin K, neurokinin beta); ZNEUROK1" TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3. ENSG00000013810 LYZ sghms24951 lysozyme (renal amyloidosis) "LYSOZYME C PRECURSOR (EC 3.2.1.17) (1,4-BETA-N-ACETYLMURAMIDASE C)" lysozymes have primarily bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. ENSG00000090382